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Title: Calcium, calcium antagonism, atherosclerosis, and ischemia.
Austin Authors: Nayler, W G
Affiliation: Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1992
Publication information: Journal of Cardiovascular Pharmacology; 19 Suppl 2(): S17-21
Abstract: Calcium is a ubiquitous cation involved in a wide variety of physiological processes. Normally, cytosolic calcium is maintained within narrow limits but under certain conditions the levels rise--either because of excess calcium entry, internal release, or failure of the extrusion mechanisms. Such conditions include hypertension and myocardial ischemia. Calcium ions are also involved in the formation of atherosclerotic lesions. Hypertension, ischemic heart disease, and atherosclerosis are all amenable to calcium antagonist therapy. The efficacy of this class of drugs in the management of such a wide spectrum of disorders is in accord with the central role played by calcium in the etiology of these disorders. To some extent, however, the disorders are interrelated, with hypertension being a major risk factors for ischemic heart disease and atherosclerosis.
Gov't Doc #: 1377299
Journal: Journal of Cardiovascular Pharmacology
Type: Journal Article
Subjects: Animals
Arteriosclerosis.drug therapy.prevention & control
Coronary Disease.drug therapy.metabolism
Cytosol.drug effects.metabolism
Hypercholesterolemia.drug therapy
Hypertension.drug therapy.physiopathology
Nifedipine.therapeutic use
Nitrendipine.therapeutic use
Rats, Inbred SHR
Rats, Inbred WKY
Appears in Collections:Journal articles

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