Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22526
Title: The clinical profile of NMOSD in Australia and New Zealand.
Authors: Bukhari, Wajih;Clarke, Laura;O'Gorman, Cullen;Khalilidehkordi, Elham;Arnett, Simon;Prain, Kerri M;Woodhall, Mark;Silvestrini, Roger;Bundell, Christine S;Ramanathan, Sudarshini;Abernethy, David;Bhuta, Sandeep;Blum, Stefan;Boggild, Mike;Boundy, Karyn;Brew, Bruce J;Brownlee, Wallace;Butzkueven, Helmut;Carroll, William M;Chen, Celia;Coulthard, Alan;Dale, Russell C;Das, Chandi;Dear, Keith;Fabis-Pedrini, Marzena J;Fulcher, David;Gillis, David;Hawke, Simon;Heard, Robert;Henderson, Andrew P D;Heshmat, Saman;Hodgkinson, Suzanne;Jimenez-Sanchez, Sofia;Kilpatrick, Trevor J;King, John;Kneebone, Chris;Kornberg, Andrew J;Lechner-Scott, Jeannette;Lin, Ming-Wei;Lynch, Christopher;Macdonnell, Richard A L;Mason, Deborah F;McCombe, Pamela A;Pereira, Jennifer;Pollard, John D;Reddel, Stephen W;Shaw, Cameron;Spies, Judith;Stankovich, James;Sutton, Ian;Vucic, Steve;Walsh, Michael;Wong, Richard C;Yiu, Eppie M;Barnett, Michael H;Kermode, Allan G;Marriott, Mark P;Parratt, John;Slee, Mark;Taylor, Bruce V;Willoughby, Ernest;Wilson, Robert J;Brilot, Fabienne;Vincent, Angela;Waters, Patrick;Broadley, Simon A
Affiliation: Department of Immunopathology, Westmead Hospital, Westmead, NSW, 2145, Australia
Department of Neurology, Austin Health, Heidelberg, VIC, 3084, Australia
Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW, 2305, Australia
Department of Neurology, Townsville Hospital, Douglas, QLD, 4814, Australia
Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, 3010, Australia
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, 3010, Australia
South Western Sydney Medical School, Liverpool Hospital, University of New South Wales, Liverpool, NSW, 2170, Australia
Department of Neurology, Westmead Hospital, Westmead, NSW, 2145, Australia
Western Australian Neuroscience Research Institute, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, WA, 6009, Australia
Centre for Applied Medical Research, St Vincent's Hospital, University of New South Wales, Darlinghurst, NSW, 2010, Australia
Department of Neurology, Royal Adelaide Hospital, Adelaide, SA, 5000, Australia
Department of Neurology, Princess Alexandra Hospital, Woolloongabba, QLD, 4102, Australia
Brain Autoimmunity Group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children's Hospital, Westmead, NSW, 2145, Australia
Department of Neurology, Canberra Hospital, Garran, ACT, 2605, Australia
Menzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia
Department of Neurology, Gold Coast University Hospital, Southport, QLD, 4215, Australia
Department of Immunology, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, 4006, Australia
School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, 6009, Australia
Department of Neurology, Princess Alexandra Hospital, Wooloongabba, QLD, 4102, Australia
School of Medicine, Deakin University, Waurn Ponds, VIC, 3217, Australia
Flinders Medical Centre, Flinders University, Bedford Park, SA, 5042, Australia
Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, 2006, Australia
Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, 3010, Australia
Centre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, WA, 6009, Australia
Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, 2006, Australia
School of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC, 3010, Australia
School of Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, 4029, Australia
The Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, 2145, Australia
Department of Neurology, St Vincent's Hospital, Darlinghurst, NSW, 2010, Australia
Menzies Research Institute, University of Tasmania, Hobart, TAS, 7000, Australia
Centre for Clinical Research, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, 4029, Australia
Nuffield Department of Clinical Neurosciences, John Radcliffe Infirmary, University of Oxford, Oxford, OX3 9DU, UK
Department of Neurology, Wellington Hospital, Newtown, 6021, New Zealand
Department of Neurology, Auckland City Hospital, Grafton, 1023, New Zealand
Global Health Research Centre, Duke Kunshan University, Kunshan, Jiangsu, China
School of Medicine, University of Auckland, Grafton, 1142, New Zealand
Department of Neurology, Christchurch Hospital, Christchurch, 8140, New Zealand
School of Medicine, University of Auckland, Grafton, 1142, New Zealand
Department of Neurology, Wellington Hospital, Newtown, 6021, New Zealand
Department of Neurology, Auckland City Hospital, Grafton, 1023, New Zealand
Issue Date: 31-Jan-2020
EDate: 2020
Citation: Journal of neurology 2020-01-31
Abstract: Neuromyelitis optica spectrum disorders (NMOSD) are an inflammation of the central nervous system associated with autoantibodies to aquaporin-4. We have undertaken a clinic-based survey of NMOSD in the Australia and New Zealand populations with the aim of characterising the clinical features and establishing the value of recently revised diagnostic criteria. Cases of possible NMOSD and age and sex-matched controls with multiple sclerosis (MS) were referred from centres across Australia and New Zealand. Cases were classified as NMOSD if they met the 2015 IPND criteria and remained as suspected NMOSD if they did not. Clinical and paraclinical data were compared across the three groups. NMOSD was confirmed in 75 cases and 89 had suspected NMOSD. There were 101 controls with MS. Age at onset, relapse rates and EDSS scores were significantly higher in NMOSD than in MS. Lesions and symptoms referable to the optic nerve were more common in NMOSD whereas brainstem, cerebellar and cerebral lesions were more common in MS. Longitudinally extensive spinal cord lesions were seen in 48/71 (68%) of cases with NMOSD. Elevations of CSF, white cell count and protein were more common in NMOSD. We have confirmed a clinical pattern of NMOSD that has been seen in several geographical regions. We have demonstrated the clinical utility of the current diagnostic criteria. Distinct patterns of disease are evident in NMOSD and MS, but there remains a large number of patients with NMOSD-like features who do not meet the current diagnostic criteria for NMOSD and remain a diagnostic challenge.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22526
DOI: 10.1007/s00415-020-09716-4
ORCID: 0000-0002-9429-4307
PubMed URL: 32006158
Type: Journal Article
Subjects: Aquaporin
Autoimmune disease
Clinical features
Multiple sclerosis
Neuromyelitis optica
Appears in Collections:Journal articles

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