Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22526
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dc.contributor.authorBukhari, Wajih-
dc.contributor.authorClarke, Laura-
dc.contributor.authorO'Gorman, Cullen-
dc.contributor.authorKhalilidehkordi, Elham-
dc.contributor.authorArnett, Simon-
dc.contributor.authorPrain, Kerri M-
dc.contributor.authorWoodhall, Mark-
dc.contributor.authorSilvestrini, Roger-
dc.contributor.authorBundell, Christine S-
dc.contributor.authorRamanathan, Sudarshini-
dc.contributor.authorAbernethy, David-
dc.contributor.authorBhuta, Sandeep-
dc.contributor.authorBlum, Stefan-
dc.contributor.authorBoggild, Mike-
dc.contributor.authorBoundy, Karyn-
dc.contributor.authorBrew, Bruce J-
dc.contributor.authorBrownlee, Wallace-
dc.contributor.authorButzkueven, Helmut-
dc.contributor.authorCarroll, William M-
dc.contributor.authorChen, Celia-
dc.contributor.authorCoulthard, Alan-
dc.contributor.authorDale, Russell C-
dc.contributor.authorDas, Chandi-
dc.contributor.authorDear, Keith-
dc.contributor.authorFabis-Pedrini, Marzena J-
dc.contributor.authorFulcher, David-
dc.contributor.authorGillis, David-
dc.contributor.authorHawke, Simon-
dc.contributor.authorHeard, Robert-
dc.contributor.authorHenderson, Andrew P D-
dc.contributor.authorHeshmat, Saman-
dc.contributor.authorHodgkinson, Suzanne-
dc.contributor.authorJimenez-Sanchez, Sofia-
dc.contributor.authorKilpatrick, Trevor J-
dc.contributor.authorKing, John-
dc.contributor.authorKneebone, Chris-
dc.contributor.authorKornberg, Andrew J-
dc.contributor.authorLechner-Scott, Jeannette-
dc.contributor.authorLin, Ming-Wei-
dc.contributor.authorLynch, Christopher-
dc.contributor.authorMacdonnell, Richard A L-
dc.contributor.authorMason, Deborah F-
dc.contributor.authorMcCombe, Pamela A-
dc.contributor.authorPereira, Jennifer-
dc.contributor.authorPollard, John D-
dc.contributor.authorReddel, Stephen W-
dc.contributor.authorShaw, Cameron-
dc.contributor.authorSpies, Judith-
dc.contributor.authorStankovich, James-
dc.contributor.authorSutton, Ian-
dc.contributor.authorVucic, Steve-
dc.contributor.authorWalsh, Michael-
dc.contributor.authorWong, Richard C-
dc.contributor.authorYiu, Eppie M-
dc.contributor.authorBarnett, Michael H-
dc.contributor.authorKermode, Allan G-
dc.contributor.authorMarriott, Mark P-
dc.contributor.authorParratt, John-
dc.contributor.authorSlee, Mark-
dc.contributor.authorTaylor, Bruce V-
dc.contributor.authorWilloughby, Ernest-
dc.contributor.authorWilson, Robert J-
dc.contributor.authorBrilot, Fabienne-
dc.contributor.authorVincent, Angela-
dc.contributor.authorWaters, Patrick-
dc.contributor.authorBroadley, Simon A-
dc.date2020-
dc.date.accessioned2020-02-04T03:22:13Z-
dc.date.available2020-02-04T03:22:13Z-
dc.date.issued2020-01-31-
dc.identifier.citationJournal of neurology 2020-01-31-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/22526-
dc.description.abstractNeuromyelitis optica spectrum disorders (NMOSD) are an inflammation of the central nervous system associated with autoantibodies to aquaporin-4. We have undertaken a clinic-based survey of NMOSD in the Australia and New Zealand populations with the aim of characterising the clinical features and establishing the value of recently revised diagnostic criteria. Cases of possible NMOSD and age and sex-matched controls with multiple sclerosis (MS) were referred from centres across Australia and New Zealand. Cases were classified as NMOSD if they met the 2015 IPND criteria and remained as suspected NMOSD if they did not. Clinical and paraclinical data were compared across the three groups. NMOSD was confirmed in 75 cases and 89 had suspected NMOSD. There were 101 controls with MS. Age at onset, relapse rates and EDSS scores were significantly higher in NMOSD than in MS. Lesions and symptoms referable to the optic nerve were more common in NMOSD whereas brainstem, cerebellar and cerebral lesions were more common in MS. Longitudinally extensive spinal cord lesions were seen in 48/71 (68%) of cases with NMOSD. Elevations of CSF, white cell count and protein were more common in NMOSD. We have confirmed a clinical pattern of NMOSD that has been seen in several geographical regions. We have demonstrated the clinical utility of the current diagnostic criteria. Distinct patterns of disease are evident in NMOSD and MS, but there remains a large number of patients with NMOSD-like features who do not meet the current diagnostic criteria for NMOSD and remain a diagnostic challenge.-
dc.language.isoeng-
dc.subjectAquaporin-
dc.subjectAutoimmune disease-
dc.subjectClinical features-
dc.subjectMultiple sclerosis-
dc.subjectNeuromyelitis optica-
dc.titleThe clinical profile of NMOSD in Australia and New Zealand.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of neurology-
dc.identifier.affiliationDepartment of Immunopathology, Westmead Hospital, Westmead, NSW, 2145, Australiaen
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, VIC, 3084, Australiaen
dc.identifier.affiliationHunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW, 2305, Australiaen
dc.identifier.affiliationDepartment of Neurology, Townsville Hospital, Douglas, QLD, 4814, Australiaen
dc.identifier.affiliationDepartment of Neurology, Royal Melbourne Hospital, Parkville, VIC, 3010, Australiaen
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, 3010, Australiaen
dc.identifier.affiliationSouth Western Sydney Medical School, Liverpool Hospital, University of New South Wales, Liverpool, NSW, 2170, Australiaen
dc.identifier.affiliationDepartment of Neurology, Westmead Hospital, Westmead, NSW, 2145, Australiaen
dc.identifier.affiliationWestern Australian Neuroscience Research Institute, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, WA, 6009, Australiaen
dc.identifier.affiliationCentre for Applied Medical Research, St Vincent's Hospital, University of New South Wales, Darlinghurst, NSW, 2010, Australiaen
dc.identifier.affiliationDepartment of Neurology, Royal Adelaide Hospital, Adelaide, SA, 5000, Australiaen
dc.identifier.affiliationDepartment of Neurology, Princess Alexandra Hospital, Woolloongabba, QLD, 4102, Australiaen
dc.identifier.affiliationBrain Autoimmunity Group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children's Hospital, Westmead, NSW, 2145, Australiaen
dc.identifier.affiliationDepartment of Neurology, Canberra Hospital, Garran, ACT, 2605, Australiaen
dc.identifier.affiliationMenzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australiaen
dc.identifier.affiliationDepartment of Neurology, Gold Coast University Hospital, Southport, QLD, 4215, Australiaen
dc.identifier.affiliationDepartment of Immunology, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, 4006, Australiaen
dc.identifier.affiliationSchool of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, 6009, Australiaen
dc.identifier.affiliationDepartment of Neurology, Princess Alexandra Hospital, Wooloongabba, QLD, 4102, Australiaen
dc.identifier.affiliationSchool of Medicine, Deakin University, Waurn Ponds, VIC, 3217, Australiaen
dc.identifier.affiliationFlinders Medical Centre, Flinders University, Bedford Park, SA, 5042, Australiaen
dc.identifier.affiliationSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, 2006, Australiaen
dc.identifier.affiliationMelbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, 3010, Australiaen
dc.identifier.affiliationCentre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, WA, 6009, Australiaen
dc.identifier.affiliationBrain and Mind Research Institute, University of Sydney, Camperdown, NSW, 2006, Australiaen
dc.identifier.affiliationSchool of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC, 3010, Australiaen
dc.identifier.affiliationSchool of Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, 4029, Australiaen
dc.identifier.affiliationThe Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, 2145, Australiaen
dc.identifier.affiliationDepartment of Neurology, St Vincent's Hospital, Darlinghurst, NSW, 2010, Australiaen
dc.identifier.affiliationMenzies Research Institute, University of Tasmania, Hobart, TAS, 7000, Australiaen
dc.identifier.affiliationCentre for Clinical Research, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, 4029, Australiaen
dc.identifier.affiliationNuffield Department of Clinical Neurosciences, John Radcliffe Infirmary, University of Oxford, Oxford, OX3 9DU, UK-
dc.identifier.affiliationDepartment of Neurology, Wellington Hospital, Newtown, 6021, New Zealand-
dc.identifier.affiliationDepartment of Neurology, Auckland City Hospital, Grafton, 1023, New Zealand-
dc.identifier.affiliationGlobal Health Research Centre, Duke Kunshan University, Kunshan, Jiangsu, China-
dc.identifier.affiliationSchool of Medicine, University of Auckland, Grafton, 1142, New Zealand-
dc.identifier.affiliationDepartment of Neurology, Christchurch Hospital, Christchurch, 8140, New Zealand-
dc.identifier.affiliationSchool of Medicine, University of Auckland, Grafton, 1142, New Zealand-
dc.identifier.affiliationDepartment of Neurology, Wellington Hospital, Newtown, 6021, New Zealand-
dc.identifier.affiliationDepartment of Neurology, Auckland City Hospital, Grafton, 1023, New Zealand-
dc.identifier.doi10.1007/s00415-020-09716-4-
dc.identifier.orcid0000-0002-9429-4307-
dc.identifier.pubmedid32006158-
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