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|Title:||Neuromyelitis Optica Spectrum Disorder and Anti-Aquaporin 4 Channel Immunoglobulin in an Australian Pediatric Demyelination Cohort.|
|Authors:||Dahan, Ariel;Brilot, Fabienne;Leventer, Richard;Kornberg, Andrew J;Dale, Russell C;Yiu, Eppie M|
|Affiliation:||Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia|
University of Sydney, Sydney, New South Wales, Australia
Department of Neurology, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
Neurosciences Research, Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
Department of Radiology, Austin Health, Heidelberg, Victoria, Australia
Kids Neuroscience Centre, Children's Hospital Westmead, Westmead, New South Wales, Australia
|Citation:||Journal of child neurology 2020: online first: 3 January|
|Abstract:||Neuromyelitis optica spectrum disorder is uncommon in children, and often seronegative for aquaporin-4 immunoglobulin G (AQP4-IgG). We conducted a retrospective study of 67 children presenting to a single Australian center with acquired demyelinating syndromes over a 7-year period. All patients were tested for AQP4-IgG. Five children (7.5%) had neuromyelitis optica spectrum disorder. One child was seropositive for AQP4-IgG (1.5%) and had a relapsing disease course with mild residual deficits. She also had a concomitant motor axonal neuropathy that improved with immunosuppressive therapy. Of the remaining 4 children, 3 had a monophasic course and 1 a relapsing course. Two were tested for anti-myelin oligodendrocyte glycoprotein (anti-MOG) antibody and both were seropositive. This study confirms that neuromyelitis optica spectrum disorder is uncommon in children, and that AQP4-IgG seropositivity is rare. Anti-MOG antibodies should be tested in children with neuromyelitis optica spectrum disorder.|
myelin oligodendrocyte glycoprotein
|Appears in Collections:||Journal articles|
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