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dc.contributor.authorDahan, Ariel-
dc.contributor.authorBrilot, Fabienne-
dc.contributor.authorLeventer, Richard-
dc.contributor.authorKornberg, Andrew J-
dc.contributor.authorDale, Russell C-
dc.contributor.authorYiu, Eppie M-
dc.identifier.citationJournal of child neurology 2020: online first: 3 January-
dc.description.abstractNeuromyelitis optica spectrum disorder is uncommon in children, and often seronegative for aquaporin-4 immunoglobulin G (AQP4-IgG). We conducted a retrospective study of 67 children presenting to a single Australian center with acquired demyelinating syndromes over a 7-year period. All patients were tested for AQP4-IgG. Five children (7.5%) had neuromyelitis optica spectrum disorder. One child was seropositive for AQP4-IgG (1.5%) and had a relapsing disease course with mild residual deficits. She also had a concomitant motor axonal neuropathy that improved with immunosuppressive therapy. Of the remaining 4 children, 3 had a monophasic course and 1 a relapsing course. Two were tested for anti-myelin oligodendrocyte glycoprotein (anti-MOG) antibody and both were seropositive. This study confirms that neuromyelitis optica spectrum disorder is uncommon in children, and that AQP4-IgG seropositivity is rare. Anti-MOG antibodies should be tested in children with neuromyelitis optica spectrum disorder.-
dc.subjectmyelin oligodendrocyte glycoprotein-
dc.subjectneuromyelitis optica-
dc.titleNeuromyelitis Optica Spectrum Disorder and Anti-Aquaporin 4 Channel Immunoglobulin in an Australian Pediatric Demyelination Cohort.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of child neurology-
dc.identifier.affiliationDepartment of Paediatrics, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationUniversity of Sydney, Sydney, New South Wales, Australiaen
dc.identifier.affiliationDepartment of Neurology, Royal Children's Hospital Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationNeurosciences Research, Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Radiology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationKids Neuroscience Centre, Children's Hospital Westmead, Westmead, New South Wales, Australiaen
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