Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16278
Title: Travel vaccination recommendations and endemic infection risks in solid organ transplantation recipients
Authors: Trubiano, Jason A;Johnson, Douglas F;Sohail, Asma;Torresi, Joseph
Issue Date: 13-Sep-2016
EDate: 2016-09-13
Citation: Journal of Travel Medicine 2016; online first: 13 September
Abstract: BACKGROUND: Solid organ transplant (SOT) recipients are often heavily immunosuppressed and consequently at risk of serious illness from vaccine preventable viral and bacterial infections or with endemic fungal and parasitic infections. We review the literature to provide guidance regarding the timing and appropriateness of vaccination and pathogen avoidance related to the immunological status of SOT recipients. METHODS: A PUBMED search ([Vaccination OR vaccine] AND/OR ["specific vaccine"] AND/OR [immunology OR immune response OR cytokine OR T lymphocyte] AND transplant was performed. A review of the literature was performed in order to develop recommendations on vaccination for SOT recipients travelling to high-risk destinations. RESULTS: Whilst immunological failure of vaccination in SOT is primarily the result of impaired B-cell responses, the role of T-cells in vaccine failure and success remains unknown. Vaccination should be initiated at least 4 weeks prior to SOT or more than 6 months post-SOT. Avoidance of live vaccination is generally recommended, although some live vaccines may be considered in the specific situations (e.g. yellow fever). The practicing physician requires a detailed understanding of region-specific endemic pathogen risks. CONCLUSIONS: We provide a vaccination and endemic pathogen guide for physicians and travel clinics involved in the care of SOT recipients. In addition, recommendations based on timing of anticipated immunological recovery and available evidence regarding vaccine immunogenicity in SOT recipients are provided to help guide pre-travel consultations.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16278
DOI: 10.1093/jtm/taw058
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/27625399
Type: Journal Article
Subjects: Solid organ transplant
Antibody response
Travel
Vaccination
Appears in Collections:Journal articles

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