Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12463
Title: Impact of vanB vancomycin-resistant enterococcal bacteraemia analysed as a time-varying covariate on length of hospital stay.
Authors: Cheah, A L Y;Spelman, T;Peel, T;Howden, Benjamin P;Spelman, D;Grayson, M Lindsay;Nation, R L;Kong, D C M
Affiliation: Centre for Population Health,Burnet Institute,Prahran, Victoria,Australia.
Department of Surgery, St Vincent's Health,University of Melbourne,Melbourne,Australia.
Department of Infectious Diseases, The Alfred, Melbourne, Victoria,Australia.
Infectious Diseases Department,Austin Health,Heidelberg, Victoria,Australia.
Centre for Medicine Use and Safety,Monash University,Parkville, Victoria,Australia.
Issue Date: 1-Dec-2014
Citation: Epidemiology and Infection; 142(12): 2667-71
Abstract: The impact of vanB vancomycin-resistant enterococci (VRE) bacteraemia on length of stay (LOS) in hospital, after adjusting for the time-varying nature of enterococcal bacteraemia (variable onset of bacteraemia post-admission), is unknown. Survival analyses (time-varying Cox and competing risks regression) were performed on vanB VRE bacteraemia patients, matched 1:1 with vancomycin-susceptible enterococci bacteraemia patients to determine the factors associated with LOS in these patients. In Cox regression analysis, vanB VRE bacteraemia, intensive-care-unit admission, Charlson co-morbidity index score ⩾4, and an increase in the time to receive appropriate antibiotics were associated with prolonged LOS. Competing risks regression which accounts for the influence of in-patient mortality on the ability to observe the event discharge alive from hospital suggests that, vanB VRE bacteraemia was not significantly associated with prolonged LOS. For the first time, the rate of discharge from hospital in patients with vanB VRE bacteraemia has been quantified.
Internal ID Number: 25372228
URI: http://ahro.austin.org.au/austinjspui/handle/1/12463
DOI: 10.1017/S095026881400020X
URL: http://www.ncbi.nlm.nih.gov/pubmed/25372228
Type: Journal Article
Subjects: Anti-Bacterial Agents.therapeutic use
Bacteremia.drug therapy.microbiology.mortality
Cross Infection.drug therapy.microbiology.mortality
Female
Humans
Length of Stay.statistics & numerical data
Male
Survival Analysis
Vancomycin Resistance
Vancomycin-Resistant Enterococci.drug effects.isolation & purification
Appears in Collections:Journal articles

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