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Title: Impact of vanB vancomycin-resistant enterococcal bacteraemia analysed as a time-varying covariate on length of hospital stay.
Austin Authors: Cheah, A L Y;Spelman, T;Peel, T;Howden, Benjamin P ;Spelman, D;Grayson, M Lindsay ;Nation, R L;Kong, D C M
Affiliation: Infectious Diseases Department,Austin Health,Heidelberg, Victoria,Australia
Centre for Population Health,Burnet Institute,Prahran, Victoria,Australia
Centre for Medicine Use and Safety,Monash University,Parkville, Victoria,Australia
Department of Infectious Diseases, The Alfred, Melbourne, Victoria,Australia
Department of Surgery, St Vincent's Health,University of Melbourne,Melbourne,Australia
Issue Date: 1-Dec-2014
Publication information: Epidemiology and Infection; 142(12): 2667-71
Abstract: The impact of vanB vancomycin-resistant enterococci (VRE) bacteraemia on length of stay (LOS) in hospital, after adjusting for the time-varying nature of enterococcal bacteraemia (variable onset of bacteraemia post-admission), is unknown. Survival analyses (time-varying Cox and competing risks regression) were performed on vanB VRE bacteraemia patients, matched 1:1 with vancomycin-susceptible enterococci bacteraemia patients to determine the factors associated with LOS in these patients. In Cox regression analysis, vanB VRE bacteraemia, intensive-care-unit admission, Charlson co-morbidity index score ⩾4, and an increase in the time to receive appropriate antibiotics were associated with prolonged LOS. Competing risks regression which accounts for the influence of in-patient mortality on the ability to observe the event discharge alive from hospital suggests that, vanB VRE bacteraemia was not significantly associated with prolonged LOS. For the first time, the rate of discharge from hospital in patients with vanB VRE bacteraemia has been quantified.
Gov't Doc #: 25372228
DOI: 10.1017/S095026881400020X
Type: Journal Article
Subjects: Anti-Bacterial Agents.therapeutic use
Bacteremia.drug therapy.microbiology.mortality
Cross Infection.drug therapy.microbiology.mortality
Length of Stay.statistics & numerical data
Survival Analysis
Vancomycin Resistance
Vancomycin-Resistant Enterococci.drug effects.isolation & purification
Appears in Collections:Journal articles

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