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Title: Spinal drop metastasis from grade I skull base chondrosarcoma.
Authors: Hall, Nick D P;Fabinyi, Gavin;Gul, Shahid M;Cher, Lawrence M;Leibsch, Norbert J
Affiliation: Department of Neurosurgery, Austin Hospital, PO Box 5555, Heidelberg, Victoria 3084, Australia
Issue Date: 27-Oct-2009
Citation: Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 2009; 17(1): 135-7
Abstract: Chondrosarcoma of the skull base is a rare tumour with a good prognosis following surgical resection. We describe a patient with low-grade chondrosarcoma of the skull base with intradural extramedullary spinal metastases. A 31-year-old female with grade 1 chondrosarcoma involving the cavernous sinus, sphenoid wing and clivus presented at age 19. The tumour was subtotally excised at initial surgery and over the following 4 years, 3 subsequent resections were undertaken for tumour progression followed by proton beam radiotherapy to the residual tumour. The patient re-presented with cervical radiculopathy 7 years later. MRI showed multiple, intradural extramedullary spinal drop metastases. Following surgical excision of the symptomatic lesion, histological diagnosis was confirmed as a mixed hyaline/myxoid grade 1 chondrosarcoma. Patients with skull base chondrosarcoma with intradural extension should have whole spine imaging as part of long-term monitoring to exclude drop metastases, particularly after intradural surgery.
Internal ID Number: 19864142
DOI: 10.1016/j.jocn.2009.02.033
Type: Journal Article
Subjects: Adult
Cranial Fossa,
Cranial Fossa,
Magnetic Resonance Imaging
Neoplasm Metastasis.pathology.therapy
Neurosurgical Procedures.methods
Skull Base
Spinal Cord Compression.etiology.pathology.physiopathology
Treatment Outcome
Appears in Collections:Journal articles

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