Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9971
Title: The use of CO2 laser in the treatment of oral white patches: outcomes and factors affecting recurrence.
Authors: Chandu, Arun;Smith, Andrew C H
Affiliation: Oral and Maxillofacial Surgery, Austin Health, Heidelberg, Vic., Australia.
Issue Date: 24-Jan-2005
Citation: International Journal of Oral and Maxillofacial Surgery 2005; 34(4): 396-400
Abstract: Laser therapy has been a favoured treatment regime for oral leukoplakia since the mid 1980s. There is no information in the literature regarding factors affecting outcomes in patients with oral leukoplakia. Forty-three patients (mean age 60.3+/-13.6 years) with 73 primary oral leukoplakia were assessed for outcome and factors affecting survival. Dysplastic lesions were found in the majority of patients. The male to female ratio was 1.7:1 with 74% ex- or current smokers, 27% consuming alcohol and 31% continuing to smoke after treatment. The mean observation time was 47.2+/-28.2 months (range 2-102 months). Disease-free survival was 55.4% at 3 years that dropped to 33.9% after 5 years. The malignant transformation rate was 7.3%. No significant prognostic factors were found on univariate analysis but alcohol consumption (P=0.034) and previous malignancy (P=0.018) were found to be significant prognostic indicators using multivariate analysis. Continuation to smoke approached significance (P=0.061). Similar disease-free survival and malignant transformation rates with minimal complications were found as compared to the literature. Recommendations for minimizing recurrence are presented. Long-term follow up and removal of aetiological factors, such as smoking and alcohol, are advised.
Internal ID Number: 16053849
URI: http://ahro.austin.org.au/austinjspui/handle/1/9971
DOI: 10.1016/j.ijom.2004.10.003
URL: http://www.ncbi.nlm.nih.gov/pubmed/16053849
Type: Journal Article
Subjects: Adult
Aged
Alcohol Drinking.adverse effects
Carbon Dioxide
Disease-Free Survival
Female
Humans
Laser Therapy
Leukoplakia, Oral.surgery
Male
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local.etiology
Proportional Hazards Models
Retrospective Studies
Risk Factors
Smoking.adverse effects
Treatment Outcome
Appears in Collections:Journal articles

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