Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9963
Title: Simplified quantification of nicotinic receptors with 2[18F]F-A-85380 PET.
Authors: Mitkovski, Sascha;Villemagne, Victor L;Novakovic, Kathy E;O'Keefe, Graeme J;Tochon-Danguy, Henri;Mulligan, Rachel S;Dickinson, Kerryn L;Saunder, Tim;Gregoire, Marie-Claude;Bottlaender, Michel;Dolle, Frederic;Rowe, Christopher C
Affiliation: Department of Nuclear Medicine and Centre for PET, Austin Hospital, Victoria 3084, Melbourne, Australia.
Issue Date: 1-Aug-2005
Citation: Nuclear Medicine and Biology; 32(6): 585-91
Abstract: Neuronal nicotinic acetylcholine receptors (nAChRs), widely distributed in the human brain, are implicated in various neurophysiological processes as well as being particularly affected in neurodegenerative conditions such as Alzheimer's disease. We sought to evaluate a minimally invasive method for quantification of nAChR distribution in the normal human brain, suitable for routine clinical application, using 2[(18)F]F-A-85380 and positron emission tomography (PET).Ten normal volunteers (four females and six males, aged 63.40+/-9.22 years) underwent a dynamic 120-min PET scan after injection of 226 MBq 2[(18)F]F-A-85380 along with arterial blood sampling. Regional binding was assessed through standardized uptake value (SUV) and distribution volumes (DV) obtained using both compartmental (DV(2CM)) and graphical analysis (DV(Logan)). A simplified approach to the estimation of DV (DV(simplified)), defined as the region-to-plasma ratio at apparent steady state (90-120 min post injection), was compared with the other quantification approaches.DV(Logan) values were higher than DV(2CM). A strong correlation was observed between DV(simplified), DV(Logan) (r=.94) and DV(2CM) (r=.90) in cortical regions, with lower correlations in thalamus (r=.71 and .82, respectively). Standardized uptake value showed low correlation against DV(Logan) and DV(2CM).DV(simplified) determined by the ratio of tissue to metabolite-corrected plasma using a single 90- to 120-min PET acquisition appears acceptable for quantification of cortical nAChR binding with 2[(18)F]F-A-85380 and suitable for clinical application.
Internal ID Number: 16026705
URI: http://ahro.austin.org.au/austinjspui/handle/1/9963
DOI: 10.1016/j.nucmedbio.2005.04.013
URL: http://www.ncbi.nlm.nih.gov/pubmed/16026705
Type: Journal Article
Subjects: Azetidines.diagnostic use.pharmacokinetics
Blood Specimen Collection
Brain.metabolism.radionuclide imaging
Brain Mapping
Female
Fluorine Radioisotopes.diagnostic use.pharmacokinetics
Humans
Image Interpretation, Computer-Assisted
Kinetics
Male
Metabolic Clearance Rate
Middle Aged
Positron-Emission Tomography.methods
Pyridines.diagnostic use.pharmacokinetics
Radiopharmaceuticals.diagnostic use.pharmacokinetics
Receptors, Nicotinic.metabolism
Tissue Distribution
Appears in Collections:Journal articles

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