Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9957
Title: Androgen regulation of satellite cell function.
Authors: Chen, Yue;Zajac, Jeffrey D;MacLean, Helen E
Affiliation: Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia.
Issue Date: 1-Jul-2005
Citation: The Journal of Endocrinology; 186(1): 21-31
Abstract: Androgen treatment can enhance the size and strength of muscle. However, the mechanisms of androgen action in skeletal muscle are poorly understood. This review discusses potential mechanisms by which androgens regulate satellite cell activation and function. Studies have demonstrated that androgen administration increases satellite cell numbers in animals and humans in a dose-dependent manner. Moreover, androgens increase androgen receptor levels in satellite cells. In vitro, the results are contradictory as to whether androgens regulate satellite cell proliferation or differentiation. IGF-I is one major target of androgen action in satellite cells. In addition, the possibility of non-genomic actions of androgens on satellite cells is discussed. In summary, this review focuses on exploring potential mechanisms through which androgens regulate satellite cells, by analyzing developments from research in this area.
Internal ID Number: 16002532
URI: http://ahro.austin.org.au/austinjspui/handle/1/9957
DOI: 10.1677/joe.1.05976
URL: http://www.ncbi.nlm.nih.gov/pubmed/16002532
Type: Journal Article
Subjects: Aging.drug effects
Androgens.physiology
Animals
Cell Differentiation.drug effects
Cell Proliferation.drug effects
Humans
Hypogonadism.drug therapy.metabolism.pathology
Insulin-Like Growth Factor I.metabolism
Myoblasts.cytology
Receptors, Androgen.metabolism
Satellite Cells, Skeletal Muscle.cytology.drug effects.metabolism
Appears in Collections:Journal articles

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