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Title: Adenovirus tubulointerstitial nephritis presenting as a renal allograft space occupying lesion.
Austin Authors: Lim, Andy Kim Ho;Parsons, Sarah;Ierino, Francesco L
Affiliation: Department of Nephrology, Austin Health, Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia
Issue Date: 1-Aug-2005
Publication information: American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons; 5(8): 2062-6
Abstract: This report describes a case of adenovirus infection in a renal allograft 36 days after transplantation that presented with transient macroscopic hematuria, prominent systemic features and acute renal dysfunction. The patient had persistent high fevers despite broad antibiotic cover. A CT scan demonstrated a new discrete space occupying lesion in the allograft, which was devoid of blood flow on Doppler sonography. A targeted renal biopsy showed florid and focal necrotizing interstitial nephritis with intranuclear tubular viral inclusions. Treatment with ganciclovir and reduction in immunosuppression resulted in a rapid improvement. Immunohistochemistry and electron microscopy confirmed adenovirus infection. This case demonstrates an uncommon presentation of necrotizing adenoviral nephropathy, which should be considered in cases of renal allograft mass lesions.
Gov't Doc #: 15996261
DOI: 10.1111/j.1600-6143.2005.00945.x
Type: Journal Article
Subjects: Adenoviridae.isolation & purification
Adenovirus Infections, Human.pathology
Inclusion Bodies, Viral.pathology
Kidney Transplantation
Kidney Tubular Necrosis, Acute.pathology.virology
Middle Aged
Nephritis, Interstitial.pathology.virology
Postoperative Complications.etiology
Transplantation, Homologous
Appears in Collections:Journal articles

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