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Title: Hepatitis due to nitrofurantoin.
Austin Authors: Mollison, L C;Angus, Peter W ;Richards, Michael J;Jones, Robert M ;Ireton, J
Affiliation: Austin Hospital, Heidelberg, VIC.
Issue Date: 2-Mar-1992
Publication information: Medical Journal of Australia; 156(5): 347-9
Abstract: To report three cases of hepatitis related to the use of nitrofurantoin.Two patients who had been taking nitrofurantoin for several years, presented with severe liver failure. In both, the drug had been continued despite evidence of liver injury. A third patient presented with acute hepatitis after six weeks of nitrofurantoin therapy.One of the patients with liver failure died and the other underwent a successful liver transplantation. The third patient recovered after withdrawal of the drug.These cases emphasise the potential for serious hepatic reactions with nitrofurantoin, the danger of continuing the drug once liver damage has occurred and the need for careful monitoring of liver function during long-term therapy.
Gov't Doc #: 1588868
Type: Journal Article
Subjects: Adult
Drug-Induced Liver Injury.etiology
Hepatic Encephalopathy.chemically induced
Middle Aged
Nitrofurantoin.adverse effects
Appears in Collections:Journal articles

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