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Title: What do antineutrophil cytoplasmic antibodies (ANCA) tell us?
Austin Authors: Savige, Judy A;Pollock, Wendy;Trevisin, Michelle
Affiliation: Department of Medicine, The Northern Hospital, Austin Health/Northern Health, University of Melbourne, Epping, Vic. 3076, Australia
Issue Date: 1-Apr-2005
Publication information: Best Practice & Research. Clinical Rheumatology; 19(2): 263-76
Abstract: Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against antigens found in the cytoplasmic granules of neutrophils and monocytes. ANCA testing is usually performed to help diagnose or exclude Wegener's granulomatosis and microscopic polyangiitis. The three most commonly used assays are indirect immunofluorescence (IIF) and the direct and 'capture' enzyme-linked immunosorbent assays (ELISAs) for ANCA directed against proteinase 3 (PR3) and myeloperoxidase (MPO). Although the International Consensus Statement for Testing and Reporting ANCA recommends that all sera are screened for ANCA by IIF and that IIF-positivity is confirmed by direct ELISAs, some laboratories test by direct ELISA alone, others screen with direct ELISA and confirm positive sera by IIF, and a few use capture ELISAs. This chapter discusses the various forms of vasculitis associated with ANCA, the usefulness of each of the ANCA assays and how ANCA testing can be used in the management of patients with small-vessel vasculitis.
Gov't Doc #: 15857795
DOI: 10.1016/j.berh.2004.10.003
Type: Journal Article
Subjects: Antibodies, Antineutrophil Cytoplasmic.blood.diagnostic use
Sensitivity and Specificity
Appears in Collections:Journal articles

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