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Title: Association of fulminant non-A non-B hepatitis with homozygosity for HLA A1-B8-DR3.
Austin Authors: Gow, Paul J ;Hathaway, Mark;Gunson, Bridget;Heward, Joanne;Mutimer, David
Affiliation: Gastroenterology Unit and Liver Transplant Unit, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Apr-2005
Publication information: Journal of Gastroenterology and Hepatology; 20(4): 555-61
Abstract: For the majority of cases of acute liver failure in western Europe and North America an etiology cannot be defined. The condition is most often called fulminant non-A, non-B (NANB) hepatitis. Features such as female preponderance and presence of serum autoantibodies suggest a possible autoimmune basis. The aim of the present paper was to examine a possible human leukocyte antigen (HLA) association with fulminant NANB hepatitis.HLA A, B, and DR data of 55 adult Caucasian fulminant NANB patients were compared with those of 1449 local Caucasian controls.In Caucasian patients, homozygosity (but not heterozygosity) for the alleles A1, B8, and DR3 were associated with fulminant NANB hepatitis (Pcorrected = 0.02, <0.00001 and 0.002, respectively). Greatest relative risk (RR) was associated with homozygosity for the A1-B8-DR3 haplotype (P < 0.00001; RR: 12.8; 95% confidence interval [CI]: 5.7-22.3). HLA DR8 was also associated with development of the syndrome (RR: 4.2; 95%CI: 1.6-9.2).Homozygosity for the HLA haplotype A1-B8-DR3 confers susceptibility to the development of fulminant NANB hepatitis. This observation may imply a role for the immune response genes (which are flanked by HLA B and DR) in the pathogenesis of this syndrome.
Gov't Doc #: 15836703
DOI: 10.1111/j.1440-1746.2005.03605.x
Type: Journal Article
Subjects: Adult
Case-Control Studies
Chi-Square Distribution
European Continental Ancestry Group
HLA Antigens.genetics
Hepatitis C.genetics.immunology
Linkage Disequilibrium
Liver Transplantation
Polymerase Chain Reaction
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