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Title: Non-invasive measurement of intrapulmonary shunt during inert gas rebreathing.
Austin Authors: Peyton, Philip J ;Poustie, Stephanie J;Robinson, Gavin J B;Penny, Daniel J;Thompson, Bruce R
Affiliation: Department of Anaesthesia, Austin Hospital, Melbourne, Victoria 3084, Australia
Issue Date: 11-Mar-2005
Publication information: Physiological Measurement 2005; 26(3): 309-16
Abstract: We tested the agreement between non-invasive measurement of intrapulmonary shunt, using oxygen uptake and pulmonary capillary blood flow measurement obtained by nitrous oxide rebreathing, with that measured using mixed venous blood sampling. Nine patients were recruited pre- and post-cardiac surgery resulting in 20 sets of measurements overall. Mean shunt fraction was 12.5%, and bias between methods (+/-95% confidence limits) was -0.7% (+/-0.8%). The standard deviation of the difference was 1.7% with limits of agreement between the two methods of +2.6% and -3.9%. Correlation coefficient r was 0.90. Agreement with the invasive standard was less accurate and precise where cardiac output was measured by bolus thermodilution (mean bias +1.6%, standard deviation of the difference 2.2%, limits of agreement between the two methods of +5.8% and -2.8%, r = 0.86). Good agreement was demonstrated between the non-invasive method and the invasive reference standard.
Gov't Doc #: 15798304
DOI: 10.1088/0967-3334/26/3/014
Journal: Physiological measurement
Type: Journal Article
Subjects: Adult
Diagnosis, Computer-Assisted.methods
Lung.blood supply.physiology
Middle Aged
Nitrous Oxide.diagnostic use.metabolism
Noble Gases.metabolism
Pulmonary Circulation.physiology
Reproducibility of Results
Respiratory Function Tests.methods
Sensitivity and Specificity
Ventilation-Perfusion Ratio.physiology
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