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Title: Flucloxacillin-induced aplastic anaemia and liver failure.
Austin Authors: Dobson, Jacqui L;Angus, Peter W ;Jones, Robert M ;Crowley, Peter;Gow, Paul J 
Affiliation: Department of Gastroenterology and Hepatology, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Apr-2005
Publication information: Transplant International : Official Journal of the European Society For Organ Transplantation; 18(4): 487-9
Abstract: Flucloxacillin is a commonly prescribed semisynthetic penicillinase-resistant penicillin primarily used for the treatment of cutaneous staphylococcal infections. It is well-recognized that flucloxacillin may occasionally result in fatal hepatic injury. We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin. At the time of transplantation the patient was severely neutropenic. Post-transplant, the patient received single donor leucocyte transfusions, which resulted in a dramatic increase in neutrophil count. The patient was discharged from hospital after 120 days with normal liver function and recovered bone marrow. In this report, we discuss the care of patients with aplastic anaemia in the peritransplant setting.
Gov't Doc #: 15773973
DOI: 10.1111/j.1432-2277.2004.00014.x
Journal: Transplant international : official journal of the European Society for Organ Transplantation
Type: Journal Article
Subjects: Adult
Anemia, Aplastic.chemically induced.therapy
Anti-Bacterial Agents.adverse effects.therapeutic use
Floxacillin.adverse effects.therapeutic use
Leukocyte Count
Leukocyte Transfusion
Liver Failure.chemically
Liver Transplantation
Postoperative Care
Skin Diseases, Bacterial.drug therapy
Appears in Collections:Journal articles

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