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Title: Effect of prior cognitive state on resting state networks measured with functional connectivity.
Austin Authors: Waites, Anthony B;Stanislavsky, Alexandra;Abbott, David F ;Jackson, Graeme D 
Affiliation: Brain Research Institute, Austin Health, Heidelberg West, Australia
Issue Date: 1-Jan-2005
Publication information: Human Brain Mapping; 24(1): 59-68
Abstract: To address the extent to which functional connectivity measures an absolute brain state, we observed the effect of prior performance of a language task on resting-state networks in regions associated with language. Six subjects were imaged during rest before and after a block-design language task. Connectivity maps were generated for each of four language regions (identified from analysis of the language activation portion of the study) in each subject for both rest periods. Conjunction analysis demonstrated distinct networks of voxels for each seed region, indicating separate functional subnetworks associated with the different regions. In a comparison of rest before and after the activation task widespread and significant changes were observed in all individuals, suggesting that the measured resting state network reflects a dynamic image of the current brain state. At the group level, an extended network was observed that was largely persistent over time. Even at the group level an increase in connectivity was observed between left and right middle frontal gyri, and between posterior cingulate cortex and medial frontal cortex in the rest after the language task. These results suggest that functional connectivity may be a powerful measure of cognitive state, sensitive to differences between controls and patients together with the particular cognitive processing occurring during the rest state.
Gov't Doc #: 15382248
DOI: 10.1002/hbm.20069
Journal: Human brain mapping
Type: Journal Article
Subjects: Brain Mapping
Cerebral Cortex.anatomy & histology.physiology
Functional Laterality.physiology
Language Tests
Magnetic Resonance Imaging
Nerve Net.anatomy & histology.physiology
Neural Pathways.anatomy & histology.physiology
Time Factors
Verbal Behavior.physiology
Appears in Collections:Journal articles

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