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Title: Functional imaging of intratumoral hypoxia.
Austin Authors: Foo, Serene S;Abbott, David F ;Lawrentschuk, Nathan;Scott, Andrew M 
Affiliation: Ludwig Institute for Cancer Research, University of Melbourne, Austin Hospital, Victoria, Australia
Issue Date: 10-Sep-2004
Publication information: Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging; 6(5): 291-305
Abstract: Tumor hypoxia plays a fundamental role in tumor progression and treatment resistance. Recent evidence that hypoxia also influences the regulation and transcription of various genes involved in malignant growth and metastases, and promotes a more aggressive tumor phenotype makes its diagnosis even more important.The evidence for the biology of hypoxia in tumors, and imaging of hypoxia with different technologies was reviewed through literature review and Medline searches, and clinical studies with 18F-fluoromisonidazole (FMISO) Positron Emission Tomography (PET).Until recently, determination of the level of tumor oxygenation was only possible using invasive methods that limited its clinical application. Imaging techniques that have shown promise in assessing hypoxia include magnetic resonance imaging and spectroscopy, single photon emission computed tomography (SPECT) and PET. Quantitative hypoxia measurement with 18F-FMISO PET in patients with malignant gliomas and lung cancer have demonstrated intratumoural hypoxia and dissociation of glucose metabolism from hypoxia in some cases, indicating the complex nature of cellular metabolic response to stress.The emerging role of therapies that have improved efficacy in hypoxic conditions, and recent advances in the ability to noninvasively measure in vivo intratumoral hypoxia with functional imaging has renewed interest in the clinical measurement of tumor hypoxia and its impact on cancer treatment.
Gov't Doc #: 15380739
DOI: 10.1016/j.mibio.2004.06.007
Type: Journal Article
Subjects: Anoxia.metabolism
Cell Hypoxia
Electron Spin Resonance Spectroscopy.trends
Magnetic Resonance Spectroscopy
Positron-Emission Tomography.trends
Tomography, Emission-Computed, Single-Photon.trends
Appears in Collections:Journal articles

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