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|Title:||Bench-to-bedside review: a brief history of clinical acid-base.||Austin Authors:||Story, David A||Affiliation:||The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia||Issue Date:||30-Apr-2004||Publication information:||Critical Care 2004; 8(4): 253-8||Abstract:||The history of assessing the acid-base equilibrium and associated disorders is intertwined with the evolution of the definition of an acid. In the 1950s clinical chemists combined the Henderson-Hasselbalch equation and the Bronsted-Lowry definition of an acid to produce the current bicarbonate ion-centred approach to metabolic acid-base disorders. Stewart repackaged pre-1950 ideas of acid-base in the late 1970s, including the Van Slyke definition of an acid. Stewart also used laws of physical chemistry to produce a new acid-base approach. This approach, using the strong ion difference (particularly the sodium chloride difference) and the concentration of weak acids (particularly albumin), pushes bicarbonate into a minor role as an acid-base indicator rather than as an important mechanism. The Stewart approach may offer new insights into acid-base disorders and therapies.||Gov't Doc #:||15312207||URI:||http://ahro.austin.org.au/austinjspui/handle/1/9790||DOI:||10.1186/cc2861||URL:||https://pubmed.ncbi.nlm.nih.gov/15312207||Type:||Journal Article||Subjects:||Acid-Base Equilibrium
Blood Gas Analysis
History, 20th Century
|Appears in Collections:||Journal articles|
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