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Title: | Complications and failure of anticoagulation therapy in the treatment of venous thromboembolism in patients with disseminated malignancy. | Austin Authors: | Chan, A;Woodruff, R K | Affiliation: | Austin Hospital, Heidelberg, Vic. | Issue Date: | 1-Apr-1992 | Publication information: | Australian and New Zealand Journal of Medicine; 22(2): 119-22 | Abstract: | Thirty-one patients with malignancy, anticoagulated for the treatment of venous thromboembolism (VTE) are reported. Complications of treatment included major bleeding (35%), redevelopment of VTE whilst on therapeutic levels of anticoagulants (13%) and recurrent VTE following cessation of anticoagulant (42%). Forty-two per cent of patients died within three months of initiating anticoagulant therapy. The cause of death was progressive malignancy, except in one patient who died of anticoagulant-related bleeding. The high incidence of bleeding is frequently associated with over-anticoagulation and indicates the need for improved monitoring. The frequent recurrence of VTE is associated with chronic disseminated intravascular coagulation, for which warfarin is ineffective and heparin is indicated. | Gov't Doc #: | 1530532 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9785 | Journal: | Australian and New Zealand Journal of Medicine | URL: | https://pubmed.ncbi.nlm.nih.gov/1530532 | Type: | Journal Article | Subjects: | Adult Aged Female Hemorrhage.chemically induced Heparin.adverse effects Humans Male Middle Aged Monitoring, Physiologic Neoplasms.complications Recurrence Thromboembolism.drug therapy.etiology Thrombophlebitis.drug therapy.etiology Treatment Outcome Warfarin.adverse effects |
Appears in Collections: | Journal articles |
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