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Title: Complications and failure of anticoagulation therapy in the treatment of venous thromboembolism in patients with disseminated malignancy.
Austin Authors: Chan, A;Woodruff, R K
Affiliation: Austin Hospital, Heidelberg, Vic.
Issue Date: 1-Apr-1992
Publication information: Australian and New Zealand Journal of Medicine; 22(2): 119-22
Abstract: Thirty-one patients with malignancy, anticoagulated for the treatment of venous thromboembolism (VTE) are reported. Complications of treatment included major bleeding (35%), redevelopment of VTE whilst on therapeutic levels of anticoagulants (13%) and recurrent VTE following cessation of anticoagulant (42%). Forty-two per cent of patients died within three months of initiating anticoagulant therapy. The cause of death was progressive malignancy, except in one patient who died of anticoagulant-related bleeding. The high incidence of bleeding is frequently associated with over-anticoagulation and indicates the need for improved monitoring. The frequent recurrence of VTE is associated with chronic disseminated intravascular coagulation, for which warfarin is ineffective and heparin is indicated.
Gov't Doc #: 1530532
Journal: Australian and New Zealand Journal of Medicine
Type: Journal Article
Subjects: Adult
Hemorrhage.chemically induced
Heparin.adverse effects
Middle Aged
Monitoring, Physiologic
Thromboembolism.drug therapy.etiology
Thrombophlebitis.drug therapy.etiology
Treatment Outcome
Warfarin.adverse effects
Appears in Collections:Journal articles

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