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Title: Is benign rolandic epilepsy genetically determined?
Austin Authors: Vadlamudi, Lata;Harvey, A Simon;Connellan, Mary M;Milne, Roger L;Hopper, John L;Scheffer, Ingrid E ;Berkovic, Samuel F 
Affiliation: Epilepsy Research Centre, Department of Medicine (Neurology), University of Melbourne, Austin Health, Australia
Issue Date: 1-Jul-2004
Publication information: Annals of Neurology; 56(1): 129-32
Abstract: Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0-0.4) for BRE compared with 0.7 (95% CI, 0.5-0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored.
Gov't Doc #: 15236411
DOI: 10.1002/ana.20153
Type: Journal Article
Subjects: Adolescent
Child, Preschool
Epilepsy, Rolandic.genetics.physiopathology
Twins, Dizygotic.genetics
Twins, Monozygotic.genetics
Appears in Collections:Journal articles

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