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https://ahro.austin.org.au/austinjspui/handle/1/9763| Title: | Is benign rolandic epilepsy genetically determined? | Austin Authors: | Vadlamudi, Lata;Harvey, A Simon;Connellan, Mary M;Milne, Roger L;Hopper, John L;Scheffer, Ingrid E ;Berkovic, Samuel F | Affiliation: | Epilepsy Research Centre, Department of Medicine (Neurology), University of Melbourne, Austin Health, Australia | Issue Date: | 1-Jul-2004 | Publication information: | Annals of Neurology; 56(1): 129-32 | Abstract: | Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0-0.4) for BRE compared with 0.7 (95% CI, 0.5-0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored. | Gov't Doc #: | 15236411 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9763 | DOI: | 10.1002/ana.20153 | Journal: | Annals of Neurology | URL: | https://pubmed.ncbi.nlm.nih.gov/15236411 | Type: | Journal Article | Subjects: | Adolescent Adult Child Child, Preschool Electroencephalography Epilepsy, Rolandic.genetics.physiopathology Female Humans Male Twins, Dizygotic.genetics Twins, Monozygotic.genetics |
| Appears in Collections: | Journal articles |
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