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Title: ACE2, a new regulator of the renin-angiotensin system.
Austin Authors: Burrell, Louise M ;Johnston, Colin I;Tikellis, Christos;Cooper, Mark E
Affiliation: Department of Medicine, University of Melbourne, Austin Health, Heidelberg Heights 3081, Australia
Issue Date: 6-May-2004
Publication information: Trends in Endocrinology and Metabolism: Tem; 15(4): 166-9
Abstract: Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin-angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents and humans with a more restricted distribution than ACE, and is found mainly in heart and kidney. ACE2 cleaves a single residue from angiotensin I (Ang I) to generate Ang 1-9, and degrades Ang II, the main effector of the RAS, to the vasodilator Ang 1-7. The importance of ACE2 in normal physiology and pathophysiological states is largely unknown. ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function.
Gov't Doc #: 15109615
DOI: 10.1016/j.tem.2004.03.001
Journal: Trends in endocrinology and metabolism: TEM
Type: Journal Article
Subjects: Animals
Peptidyl-Dipeptidase A.metabolism.physiology
Renin-Angiotensin System.physiology
Tissue Distribution
Appears in Collections:Journal articles

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