Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/9678
Title: | Nonalbuminuric renal insufficiency in type 2 diabetes. | Austin Authors: | MacIsaac, Richard J;Tsalamandris, Con;Panagiotopoulos, Sianna ;Smith, Trudy J;McNeil, Karen J;Jerums, George | Affiliation: | Endocrinology Unit, Austin Health, Heidelberg, Victoria, Australia | Issue Date: | 1-Jan-2004 | Publication information: | Diabetes Care; 27(1): 195-200 | Abstract: | To determine the prevalence and characteristics of patients with type 2 diabetes who have impaired renal function, defined as a glomerular filtration rate (GFR) <60 ml. min(-1). 1.73 m(-2), and normoalbuminuria.A cross-sectional survey of 301 outpatients attending a single tertiary referral center using the plasma disappearance of isotopic (99m)Tc-diethylene-triamine-penta-acetic acid to measure GFR and at least two measurements of urinary albumin excretion rate (AER) over 24 h to determine albuminuria.A total of 109 patients (36%) had a GFR <60 ml. min(-1). 1.73 m(-2). The overall prevalence of normo-, micro-, and macroalbuminuria was 43 of 109 (39%), 38 of 109 (35%), and 28 of 109 (26%), respectively. Compared with patients with macroalbuminuria, those with normoalbuminuria were more likely to be older and female. After excluding patients whose normoalbuminuric status was possibly related to the initiation of a renin-angiotensin system (RAS) inhibitor before the start of the study, the prevalence of a GFR <60 ml. min(-1). 1.73 m(-2) and normoalbuminuria was 23%. Temporal changes in GFR in a subset of 34 of 109 (32%) unselected patients with impaired renal function were available for comparison over a 3- to 10-year period. The rates of decline in GFR (ml. min(-1). 1.73 m(-2). year(-1)) of -4.6 +/- 1.0, -2.8 +/- 1.0, and -3.0 +/- 07 were not significantly different for normo- (n = 12), micro- (n = 12), and macroalbuminuric (n = 10) patients, respectively.These results suggest that patients with type 2 diabetes can commonly progress to a significant degree of renal impairment while remaining normoalbuminuric. | Gov't Doc #: | 14693989 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9678 | ORCID: | 0000-0002-0845-0001 | Journal: | Diabetes Care | URL: | https://pubmed.ncbi.nlm.nih.gov/14693989 | Type: | Journal Article | Subjects: | Age of Onset Aged Albuminuria.epidemiology Cross-Sectional Studies Diabetes Mellitus, Type 2.urine Diabetic Nephropathies.urine Female Glomerular Filtration Rate.physiology Humans Kidney Failure, Chronic.urine Male Victoria |
Appears in Collections: | Journal articles |
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.