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Title: Semi-quantitative determination of microalbuminuria by urinary dipstick.
Austin Authors: Gilbert, Richard E;Akdeniz, A;Jerums, George 
Affiliation: Endocrinology Unit, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Aug-1992
Publication information: Australian and New Zealand Journal of Medicine; 22(4): 334-7
Abstract: Microalbuminuria predicts subsequent clinical nephropathy and mortality in diabetic patients. This study was undertaken to determine the usefulness of a new immunochemical urinary dipstick test (Micral-Test, Boehringer Mannheim, GmbH Mannheim, Germany) in identifying urinary albumin concentrations within the microalbuminuric range (urinary albumin concentration 20-200 mg/L). Twenty-four hour urine specimens were collected from 298 consecutive diabetic outpatients. Micral-Test was performed by two laboratory scientists blinded to each other's results and those of radioimmunoassay (RIA) and immunoturbidimetry on the same specimen. When compared with RIA, Micral-Test had an overall sensitivity of 92.2%, specificity of 92.3% and positive predictive value of 86.4%. However, at the threshold value of 20 mg/1 Micral-Test showed false positive results in 37.8% of samples when compared with RIA. Similar results were obtained when Micral-Test was compared with immunoturbidimetry. We conclude that Micral-Test is a useful screening method for the detection of microalbuminuria. We suggest that positive tests be confirmed by a timed urine collection using established methodology and that patients whose Micral-Test is negative be subjected to annual retesting.
Gov't Doc #: 1445020
Type: Journal Article
Subjects: Albuminuria.diagnosis.urine
Diabetes Complications
False Positive Reactions
Nephelometry and Turbidimetry
Predictive Value of Tests
Reagent Strips.diagnostic use
Appears in Collections:Journal articles

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