Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9576
Title: Computer-aided mapping of the beta-adrenoceptor. 1. Explanation for effect of para substitution on blocking activity at the beta-1-adrenoceptor.
Austin Authors: Ball, J B;Nero, Tracy L;Iakovidis, D;Tung, L;Jackman, G;Louis, William J 
Affiliation: University of Melbourne, Department of Medicine, Austin/Repatriation Hospital, Heidelberg, Victoria, Australia
Issue Date: 11-Dec-1992
Publication information: Journal of Medicinal Chemistry; 35(25): 4676-82
Abstract: Anomalously low affinities for the beta-1-adrenoceptor are seen for members of a series of para-substituted N-isopropylphenoxypropanolamines in which the substituent is able to conjugate with the aromatic ring. The energy of conjugation was calculated using the AM1 semiempirical molecular orbital method and appears to correlate with the loss of binding energy, and hence affinity for the receptor. This suggests that binding is associated with movement of the substituent out of the plane of the aromatic ring due to steric interference with the receptor. A previously unrecognized binding site for aromatic groups off the para position is also identified.
Gov't Doc #: 1361581
URI: http://ahro.austin.org.au/austinjspui/handle/1/9576
URL: https://pubmed.ncbi.nlm.nih.gov/1361581
Type: Journal Article
Subjects: Adrenergic beta-Antagonists.chemical synthesis.metabolism.pharmacology
Computer Simulation
Propanolamines.chemical synthesis.metabolism.pharmacology
Stereoisomerism
Structure-Activity Relationship
Appears in Collections:Journal articles

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