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Title: CNS regeneration: clinical possibility or basic science fantasy?
Austin Authors: Batchelor, Peter Egerton;Howells, David William
Affiliation: Departments of Medicine and Neurology, University of Melbourne, Austin and Repatriation Medical Centre, Vic. 3084, Heidelberg, Australia
Issue Date: 1-Sep-2003
Publication information: Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia; 10(5): 523-34
Abstract: Following injury to the CNS, severed axons undergo a phase of abortive sprouting in the vicinity of the wound, but do not spontaneously re-grow or regenerate. From a long history of attempts to stimulate regeneraion, a major strategy that has been developed clinically is the implantation of tissue into denervated target regions. Unfortunately trials have so far not borne out the promise that this would prove a useful therapy for disorders such as Parkinson's disease. Many strategies have also been developed to stimulate the regeneration of axons across sites of injury, particularly in the spinal cord. Animal data have demonstrated that some of these approaches hold promise and that the spinal cord has a remarkable degree of intrinsic plasticity. Attempts are now being made to utilize experimental techniques in spinal patients.
Gov't Doc #: 12948453
Journal: Journal of Clinical Neuroscience
Type: Journal Article
Subjects: Animals
Central Nervous System Diseases.physiopathology
Models, Animal
Nerve Fibers.physiology
Nerve Regeneration.physiology
Peripheral Nerves.transplantation
Spinal Cord Diseases.physiopathology
Appears in Collections:Journal articles

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