Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9539
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dc.contributor.authorBatchelor, Peter Egertonen
dc.contributor.authorHowells, David Williamen
dc.date.accessioned2015-05-15T22:40:37Z
dc.date.available2015-05-15T22:40:37Z
dc.date.issued2003-09-01en
dc.identifier.citationJournal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia; 10(5): 523-34en
dc.identifier.govdoc12948453en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9539en
dc.description.abstractFollowing injury to the CNS, severed axons undergo a phase of abortive sprouting in the vicinity of the wound, but do not spontaneously re-grow or regenerate. From a long history of attempts to stimulate regeneraion, a major strategy that has been developed clinically is the implantation of tissue into denervated target regions. Unfortunately trials have so far not borne out the promise that this would prove a useful therapy for disorders such as Parkinson's disease. Many strategies have also been developed to stimulate the regeneration of axons across sites of injury, particularly in the spinal cord. Animal data have demonstrated that some of these approaches hold promise and that the spinal cord has a remarkable degree of intrinsic plasticity. Attempts are now being made to utilize experimental techniques in spinal patients.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCentral Nervous System Diseases.physiopathologyen
dc.subject.otherDenervationen
dc.subject.otherHumansen
dc.subject.otherInflammation.physiopathologyen
dc.subject.otherMacrophages.physiologyen
dc.subject.otherMicroglia.physiologyen
dc.subject.otherModels, Animalen
dc.subject.otherNerve Fibers.physiologyen
dc.subject.otherNerve Regeneration.physiologyen
dc.subject.otherParkinson Disease.physiopathology.surgeryen
dc.subject.otherPeripheral Nerves.transplantationen
dc.subject.otherSpinal Cord Diseases.physiopathologyen
dc.titleCNS regeneration: clinical possibility or basic science fantasy?en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Clinical Neuroscienceen
dc.identifier.affiliationDepartments of Medicine and Neurology, University of Melbourne, Austin and Repatriation Medical Centre, Vic. 3084, Heidelberg, Australiaen
dc.description.pages523-34en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12948453en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
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