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Title: Antimicrobial resistance in Helicobacter pylori isolates from children.
Austin Authors: Rerksuppaphol, S;Hardikar, W;Midolo, P D;Ward, P
Affiliation: Department of Paediatric Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Austin Hospital, Melbourne, Victoria, Australia
Issue Date: 1-Jul-2003
Publication information: Journal of Paediatrics and Child Health; 39(5): 332-5
Abstract: To determine the resistance rate to four antimicrobial agents commonly used in the treatment of Helicobacter pylori infection in children.Between July 1997 and January 2000, all H. pylori isolates from children undergoing gastroscopy were prospectively collected and subcultured to yield the susceptibility to four antimicrobial agents by E-test. In all, 23 isolates were tested. Demographic data, presenting symptoms, treatment regimen and clinical improvement after treatment were collected retrospectively.The resistance rate of H. pylori to metronidazole and clarithromycin were 43.5% and 8.7%, respectively. No H. pylori strains were resistant to amoxycillin or tetracycline. There were no statistically significant differences in age, sex, ethnicity, presenting symptoms or clinical improvement after treatment between antimicrobial-susceptible and antimicrobial-resistant groups.The frequent resistance of H. pylori to metronidazole and moderate resistance to clarithromycin in children are comparable with local adult data. The incidence of resistance tended to be higher in patients of non-European ethnicity, but this was not statistically significant. Given that the primary goal of therapy is eradication, and that local resistance rates are high, recommendations for H. pylori management may need to be modified to include sensitivity testing and/or determination of eradication in all patients.
Gov't Doc #: 12887661
Type: Journal Article
Subjects: Amoxicillin.pharmacology.therapeutic use
Anti-Bacterial Agents.pharmacology.therapeutic use
Clarithromycin.pharmacology.therapeutic use
Drug Resistance, Microbial
Helicobacter Infections.drug therapy
Helicobacter pylori.drug effects.isolation & purification
Hospitals, Pediatric
Metronidazole.pharmacology.therapeutic use
Tetracycline.pharmacology.therapeutic use
Appears in Collections:Journal articles

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