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Title: Rational approaches to human cancer immunotherapy.
Austin Authors: Davis, Ian D;Jefford, Michael;Parente, Phillip;Cebon, Jonathan S 
Affiliation: Ludwig Institute for Cancer Research, Austin & Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
Issue Date: 1-Jan-2003
Publication information: Journal of Leukocyte Biology; 73(1): 3-29
Abstract: Over most of the 20th century, immunotherapy for cancer was based on empiricism. Interesting phenomena were observed in the areas of cancer, infectious diseases, or transplantation. Inferences were made and extrapolated into new approaches for the treatment of cancer. If tumors regressed, the treatment approaches could be refined further. However, until the appropriate tools and reagents were available, investigators were unable to understand the biology underlying these observations. In the early 1990s, the first human tumor T cell antigens were defined and dendritic cells were discovered to play a pivotal role in antigen presentation. The current era of cancer immunotherapy is one of translational research based on known biology and rationally designed interventions and has led to a rapid expansion of the field. The beginning of the 21st century brings the possibility of a new era of effective cancer immunotherapy, combining rational, immunological treatments with conventional therapies to improve the outcome for patients with cancer.
Gov't Doc #: 12525559
Type: Journal Article
Subjects: Animals
Antigen-Presenting Cells.immunology.transplantation
Cancer Vaccines.therapeutic use
History, 20th Century
Immunity, Cellular.drug effects
Research Design
Appears in Collections:Journal articles

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