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Title: Evaluation of 18 F-fluorodeoxyglucose positron emission tomography and computed tomography with histopathologic correlation in the initial staging of head and neck cancer.
Austin Authors: Hannah, Anthony;Scott, Andrew M ;Tochon-Danguy, Henri;Chan, J Gordon ;Akhurst, Tim;Berlangieri, Salvatore U ;Price, David;Smith, Gerard J;Schelleman, Tony;McKay, W J;Sizeland, Andrew
Affiliation: Centre for Positron Emission Tomography, Ludwig Institute for Cancer Research, Heidelberg, Victoria, Australia
Issue Date: 1-Aug-2002
Publication information: Annals of Surgery; 236(2): 208-17
Abstract: To prospectively evaluate the use of 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) in the initial staging of squamous cell head and neck carcinoma.The status of cervical lymph nodes is an important prognostic factor and determinant of management approach in squamous cell head and neck cancer.FDG-PET findings were compared with those of computed tomography (CT) before removal of the primary tumor and/or neck dissection. Histopathologic analysis was used as the gold standard for assessment of the sensitivity and specificity of these modalities.FDG-PET correctly identified the primary tumor in 35 of 40 patients in whom the site of the primary was known clinically and still present (sensitivity 88%). None of four unknown primaries were detected. Tumors not detected by FDG-PET were generally superficial, with depths of less than 4 mm. CT correctly identified 18 of the 35 primary tumors (sensitivity 51%). Eleven of 17 CT false-negative tumors were detected by FDG-PET. The sensitivity and specificity for the presence of metastatic neck disease on FDG-PET were 82% and 100%, respectively; those for CT were 81% and 81%, respectively. FDG-PET was true positive for metastatic neck disease in two of the three CT false-negative patients.FDG-PET shows promise in the initial staging of head and neck cancer and provides additional accuracy to a conventional staging process using CT.
Gov't Doc #: 12170026
DOI: 10.1097/01.SLA.0000021592.90987.AA
Journal: Annals of surgery
Type: Journal Article
Subjects: Adult
Aged, 80 and over
Carcinoma, Squamous
Fluorodeoxyglucose F18.diagnostic use
Head and Neck
Lymphatic Metastasis
Middle Aged
Neck Dissection
Neoplasm Staging
Prospective Studies
Radiopharmaceuticals.diagnostic use
Sensitivity and Specificity
Tomography, Emission-Computed
Tomography, X-Ray Computed
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