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Title: Neurohormonal antagonism in heart failure; beneficial effects of vasopressin V(1a) and V(2) receptor blockade and ACE inhibition.
Austin Authors: Naitoh, Mareo;Risvanis, John;Balding, Leanne C;Johnston, Colin I;Burrell, Louise M 
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
Issue Date: 1-Apr-2002
Publication information: Cardiovascular Research; 54(1): 51-7
Abstract: To assess the long-term efficacy of vasopressin (AVP) V(1a) and V(2) receptor blockade with conivaptan, alone and in combination with angiotensin converting enzyme (ACE) inhibition on blood pressure, metabolic and neurohormonal parameters, and cardiovascular structure in a rat model of congestive heart failure (CHF).CHF was induced by left coronary artery ligation. CHF rats received conivaptan (1 mg/kg/day), ACE inhibition (captopril, 50 mg/kg/day), conivaptan and captopril (Combination) or vehicle for 4 weeks. Blood pressure was measured weekly, metabolic caging studies performed at 25 days, and rats killed and blood and tissue collected after 4 weeks treatment.Combination treatment lowered blood pressure (P<0.01), and conivaptan and Combination caused an aquaresis (P<0.01). Combination decreased plasma natriuretic peptide (P<0.05), reduced left and right ventricular mass (P<0.01) and lung mass (P<0.05).In CHF, blockade of vasopressin V(1a) and V(2) receptors was associated with increased water excretion, and the combination of conivaptan with ACE inhibition was the only treatment to reduce blood pressure, natriuretic peptide and pulmonary congestion. These results suggest conivaptan may be a useful addition to ACE inhibitors in the management of vasoconstriction and fluid retention that characterizes CHF.
Gov't Doc #: 12062361
Journal: Cardiovascular research
Type: Journal Article
Subjects: Analysis of Variance
Angiotensin-Converting Enzyme Inhibitors.therapeutic use
Antidiuretic Hormone Receptor Antagonists
Arginine Vasopressin.blood
Atrial Natriuretic Factor.blood
Benzazepines.therapeutic use
Blood Pressure.drug effects
Captopril.therapeutic use
Heart Failure.drug therapy.pathology
Osmolar Concentration
Rats, Sprague-Dawley
Appears in Collections:Journal articles

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