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Title: Paired associate performance in the early detection of DAT.
Austin Authors: Fowler, Kylie S;Saling, Michael M ;Conway, Elizabeth L;Semple, James M;Louis, William J 
Affiliation: Department of Neuropsychology, Austin Hospital, Victoria, Australia
Issue Date: 1-Jan-2002
Publication information: Journal of the International Neuropsychological Society : Jins; 8(1): 58-71
Abstract: Subjects underwent longitudinal neuropsychological assessment in order to retrospectively determine which measures of cognitive function best predicted later development of dementia of the Alzheimer type (DAT). Three groups of subjects were studied: normal controls, patients with early DAT, and questionable dementia subjects (QD). All subjects were assessed using a battery of standard neuropsychological measures and two subtests from the Cambridge Neuropsychological Test Automated Battery (CANTAB), paired associate learning and delayed matching to sample. A structured interview was also used to elicit a profile of the subject's daily functioning. Subjects were assessed every 6 months for 2 years. At the 6 month assessment, almost half of the QD group exhibited significant deterioration in scores on the computerized paired associate learning subtest, while maintaining their scores on standard measures. At the conclusion of the study, all of this QD subgroup fulfilled the NINCDS-ADRDA criteria for probable DAT pertaining to significant cognitive and functional deterioration. Performance on the C
Gov't Doc #: 11843075
Type: Journal Article
Subjects: Aged
Alzheimer Disease.diagnosis.psychology
Association Learning
Case-Control Studies
Cluster Analysis
Diagnosis, Differential
Follow-Up Studies
Middle Aged
Neuropsychological Tests
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
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