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Title: Evidence for activation of the renin-angiotensin system in the human prostate: increased angiotensin II and reduced AT(1) receptor expression in benign prostatic hyperplasia.
Austin Authors: Dinh, Diem T;Frauman, Albert G ;Somers, Gino R;Ohishi, Mitsuru;Zhou, Jialong;Casley, David J;Johnston, Colin I;Fabiani, Maurice E
Affiliation: Department of Medicine, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg, VIC 3084, Australia
Issue Date: 1-Feb-2002
Publication information: The Journal of Pathology; 196(2): 213-9
Abstract: The expression and cellular localization of angiotensin II (Ang II) and AT(1) receptor proteins were examined in the normal human prostate and benign prostatic hyperplasia (BPH) by immunohistochemistry. In the normal prostate, Ang II immunoreactivity was localized to the basal layer of the epithelium and AT(1) receptor immunostaining was found predominantly on stromal smooth muscle and also on vascular smooth muscle of prostatic blood vessels. Ang II immunoreactivity was markedly increased in hyperplastic acini in BPH compared with acini in the normal prostate (normal: 7.4+/-0.2%, n=5 vs. BPH: 22.7+/-1.9%, n=5, p<0.001). However, AT(1) receptor immunoreactivity was significantly decreased in BPH compared with the normal prostate [normal: 16.4+/-2.2%, n=4 vs. BPH: 9.4+/-1.3%, n=5, p<0.05 (p=0.025)]. The present study demonstrates the presence of Ang II peptide in the basal layer of the epithelium and AT(1) receptors on stromal smooth muscle, suggesting that Ang II may mediate paracrine functions on cellular growth and smooth muscle tone in the human prostate. Furthermore, AT(1) receptor down-regulation in BPH may be due to receptor hyperstimulation by increased local levels of Ang II in BPH. These data extend previous findings in support of the novel concept that overactivity of the renin-angiotensin system (RAS) may be involved in the pathophysiology of BPH.
Gov't Doc #: 11793373
DOI: 10.1002/path.1021
Journal: The Journal of pathology
Type: Journal Article
Subjects: Angiotensin I.metabolism
Angiotensin II.analysis
Case-Control Studies
Muscle, Smooth, Vascular.chemistry
Prostate.blood supply.chemistry
Prostatic Hyperplasia.metabolism
Receptors, Angiotensin.analysis
Renin-Angiotensin System.physiology
Appears in Collections:Journal articles

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