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Title: Angiotensin receptors: distribution, signalling and function.
Austin Authors: Dinh, Diem T;Frauman, Albert G ;Johnston, Colin I;Fabiani, Mark E
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Austin Campus, Studley Road, Heidelberg, VIC 3084, Australia
Issue Date: 1-May-2001
Publication information: Clinical Science 2001; 100(5): 481-92
Abstract: Angiotensin II (Ang II) is a multi-functional hormone that plays a major role in regulating blood pressure and cardiovascular homoeostasis. The actions of Ang II are mediated by at least two receptor subtypes, designated AT(1) and AT(2). In addition, other angiotensin receptors have been identified which may recognize other angiotensin peptide fragments; however, until now only the AT(1) and AT(2) receptor have been cloned in animals or humans. Most of the well-described actions of Ang II, such as vasoconstriction, facilitation of sympathetic transmission, stimulation of aldosterone release and promotion of cellular growth are all mediated by the AT(1) receptor. Much less is known about the function of the AT(2) receptor, but recent studies suggest that it may play a role in mediating anti-proliferation, cellular differentiation, apoptosis and vasodilatation. In this review, we discuss recent advances in our understanding of Ang II receptors, in particular, their distribution, signalling and function.
Gov't Doc #: 11294688
Type: Journal Article
Subjects: Angiotensin I.metabolism
Angiotensin II.metabolism
Mice, Knockout
Receptors, Angiotensin.metabolism.physiology
Renin-Angiotensin System.physiology
Signal Transduction.physiology
Appears in Collections:Journal articles

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