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Title: The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation.
Austin Authors: Cooper, Mark E;Thallas, Vicki;Forbes, J;Scalbert, E;Sastra, S;Darby, I;Soulis, T
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia
Issue Date: 1-May-2000
Publication information: Diabetologia; 43(5): 660-4
Abstract: Advanced glycation is postulated to have a pivotal role in mediating diabetic vascular complications. The emergence of thiazolium compounds such as N-phenacylthiazolium bromide which cleave preformed advanced glycation end products (AGEs) has allowed us to explore the effects of these agents on the vascular AGE accumulation and hypertrophy associated with diabetes.Control and streptozotocin diabetic rats were selected at random for no treatment or treatment with N-phenacylthiazolium bromide (10 mg/kg intraperitoneally) and followed for 3 weeks. In a separate study, intervention with N-phenacylthiazolium bromide was delayed until after 3 weeks of diabetes and then given for 3 weeks (total of 6 weeks).Diabetes was associated with increased mesenteric vascular advanced glycation end products, as assessed by radioimmunoassay and immunohistochemistry. This increase in vascular AGE accumulation was prevented by N-phenacylthiazolium bromide treatment. Diabetes-associated mesenteric vascular hypertrophy was attenuated by treatment with N-phenacylthiazolium bromide only if given from the time of induction of diabetes.Cross-link breakers seem to be effective in preventing or reversing accumulation of advanced glycation end-products in blood vessels and have the potential to play a part in the treatment of diabetic vascular complications.
Gov't Doc #: 10855541
DOI: 10.1007/s001250051355
Type: Journal Article
Subjects: Animals
Blood Pressure
Blood Vessels.chemistry.metabolism
Diabetes Mellitus, Experimental.metabolism
Glycosylation End Products, Advanced.analysis.metabolism
Hemoglobin A, Glycosylated.analysis
Rats, Sprague-Dawley
Splanchnic Circulation
Thiazoles.administration & dosage.pharmacology
Appears in Collections:Journal articles

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