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Title: Ictal SPECT and interictal PET in the localization of occipital lobe epilepsy.
Austin Authors: Sturm, Jonathan W;Newton, Mark R;Chinvarun, Y;Berlangieri, Salvatore U ;Berkovic, Samuel F 
Affiliation: Departments of Neurology, Austin and Repatriation Medical Centre, and Medicine, University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 1-Apr-2000
Publication information: Epilepsia; 41(4): 463-6
Abstract: To compare the localizing value of ictal single photon emission computed tomography (SPECT) and interictal fluorodeoxyglucose-positron emission tomography (FDG-PET) in refractory occipital lobe epilepsy.Six patients who underwent surgery for refractory epilepsy associated with pathology in the occipital lobe were retrospectively selected from records of the Austin & Repatriation Centre Comprehensive Epilepsy Programme. Interictal SPECT and PET and ictal SPECT were obtained by standard methods. All studies were read by a nuclear medicine expert blinded to clinical data except the diagnosis of epilepsy.Ictal SPECT showed unilateral occipital hyperperfusion in five of six cases often accompanied by temporal lobe hyperperfusion. These patterns were seen in cases with or without magnetic resonance imaging (MRI) abnormality. Interictal SPECT was not localizing in any case, in contrast to PET, which showed occipital hypometabolism in three of five studies.Ictal SPECT can provide novel localizing data in MRI-negative occipital lobe epilepsy. Interictal PET can provide useful localizing information, but its role in providing novel information was not demonstrated. Interictal SPECT is useful only as a baseline to aid in interpretation of ictal studies.
Gov't Doc #: 10756414
Type: Journal Article
Subjects: Adult
Age of Onset
Epilepsies, Partial.diagnosis.physiopathology.radionuclide imaging
Fluorodeoxyglucose F18.diagnostic use
Magnetic Resonance Imaging
Middle Aged
Occipital Lobe.anatomy & histology.physiopathology.radionuclide imaging
Temporal Lobe.anatomy & histology.physiopathology.radionuclide imaging
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
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