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Title: Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor.
Austin Authors: Batchelor, Peter Egerton;Liberatore, G T;Wong, J Y;Porritt, Michelle J;Frerichs, F;Donnan, Geoffrey A ;Howells, David William
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
Issue Date: 1-Mar-1999
Publication information: The Journal of Neuroscience : the Official Journal of the Society For Neuroscience; 19(5): 1708-16
Abstract: Nigrostriatal dopaminergic neurons undergo sprouting around the margins of a striatal wound. The mechanism of this periwound sprouting has been unclear. In this study, we have examined the role played by the macrophage and microglial response that follows striatal injury. Macrophages and activated microglia quickly accumulate after injury and reach their greatest numbers in the first week. Subsequently, the number of both cell types declines rapidly in the first month and thereafter more slowly. Macrophage numbers eventually cease to decline, and a sizable group of these cells remains at the wound site and forms a long-term, highly activated resident population. This population of macrophages expresses increasing amounts of glial cell line-derived neurotrophic factor mRNA with time. Brain-derived neurotrophic factor mRNA is also expressed in and around the wound site. Production of this factor is by both activated microglia and, to a lesser extent, macrophages. The production of these potent dopaminergic neurotrophic factors occurs in a similar spatial distribution to sprouting dopaminergic fibers. Moreover, dopamine transporter-positive dopaminergic neurites can be seen growing toward and embracing hemosiderin-filled wound macrophages. The dopaminergic sprouting that accompanies striatal injury thus appears to result from neurotrophic factor secretion by activated macrophages and microglia at the wound site.
Gov't Doc #: 10024357
Type: Journal Article
Subjects: Adrenergic Fibers.metabolism.physiology
Brain-Derived Neurotrophic Factor.biosynthesis
Cell Size
Corpus Striatum.injuries.physiology
Gene Expression
Glial Cell Line-Derived Neurotrophic Factor
In Situ Hybridization
Macrophage Activation.physiology
Mice, Inbred C57BL
Nerve Growth Factors
Nerve Regeneration.physiology
Nerve Tissue Proteins.biosynthesis
RNA, Messenger.biosynthesis
Wound Healing.physiology
Appears in Collections:Journal articles

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