Austin Health

Title
Evaluating diagnostic tools, outcome measures and antibiotic approach in diabetic foot osteomyelitis: a scoping review and narrative synthesis.
Publication Date
2024-12
Author(s)
Motaganahalli, Satwik
Reynolds, Gemma
Haikerwal, Suresh
Richards, Toby
Peel, Trisha N
Trubiano, Jason
Subject
Diabetic foot infection
antibiotic
diabetes
diagnostics
foot ulcer
osteomyelitis
Type of document
Journal Article
OrcId
0000-0002-6739-0424
0000-0002-9561-3592
#PLACEHOLDER_PARENT_METADATA_VALUE#
0000-0001-9872-4653
0000-0003-2370-2438
0000-0002-5111-6367
DOI
10.1080/14787210.2024.2403145
Abstract
Diabetic foot osteomyelitis (DFO) is a significant complication of diabetic foot disease; however, diagnosis remains challenging and treatment success is difficult to ascertain. Literature in this space that has utilized varying diagnostic criteria and ideal outcome measures for success is unclear. This scoping review assesses methods of diagnosis of DFO and definitions of treatment outcomes in the literature assessing antibiotic therapy for treatment of DFO. There is a lack of consensus in the design of diabetic foot trials, resulting in difficulty for clinicians to assess and manage serious conditions such as DFO. The cure for DFO is challenging to ascertain and treatment failure may be a better approach to assess outcomes in research assessing the efficacy of antibiotic therapy. In the absence of gold-standard diagnostic tools, practical approaches to outcome assessment may allow for greater clinical applicability of available data.
Link
Citation
Expert Review of Anti-infective Therapy 2024-12; 22(12)
Jornal Title
Expert Review of Anti-infective Therapy
ISSN
1744-8336

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