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Title: | Risk factors for PPCs in laparoscopic non-robotic vs. laparoscopic robotic abdominal surgery (LapRas): rationale and protocol for a patient-level analysis of LAS VEGAS and AVATaR. | Austin Authors: | Serafini, S C;Hemmes, S N T;Serpa Neto, A;Schultz, M J;Tschernko, E;Gama de Abreu, M;Mazzinari, G;Ball, L | Affiliation: | Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy; Department of Intensive Care, Amsterdam UMC, Amsterdam, Netherlands. Department of Anesthesiology, Amsterdam UMC, Amsterdam, Netherlands; Department of Anesthesiology, Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands. Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Department of Critical Care, Melbourne Medical School, Austin Hospital, University of Melbourne, Melbourne, Victoria, Australia; Department of Critical Care, Data Analytics Research and Evaluation Centre, University of Melbourne, Melbourne, Victoria, Australia; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, SP, Brasil. Department of Intensive Care, Amsterdam UMC, Amsterdam, Netherlands. Department of Anesthesiology, Intensive Care Medicine and Pain Medicine, Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine, Medical University of Vienna, Viena, Austria. Division of Intensive Care and Resuscitation, Division of Cardiothoracic Anesthesia, and Outcomes Research Consortium, Department of Anesthesiology, Integrated Hospital Care Institute, Cleveland Clinic, Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, United States. Research Group in Perioperative Medicine, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Department of Statistics and Operational Research, Universidad de Valencia, Valencia, Spain. Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy; Anesthesia and Intensive Care, Ospedale Policlinico San Martino, IRCCS per l'Oncologia e le Neuroscience, Genoa, Italy. Data Analytics Research and Evaluation (DARE) Centre cri |
Issue Date: | 8-Jul-2024 | Date: | 2024 | Publication information: | Revista Espanola de Anestesiologia y Reanimacion 2024-07-08 | Abstract: | Postoperative pulmonary complications (PPCs) vary amongst different surgical techniques. We aim to compare the incidence of PPCs after laparoscopic non-robotic versus laparoscopic robotic abdominal surgery. LapRas (Risk Factors for PPCs in Laparoscopic Non-robotic vs Laparoscopic robotic abdominal surgery) incorporates harmonized data from 2 observational studies on abdominal surgery patients and PPCs: 'Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' (LAS VEGAS), and 'Assessment of Ventilation during general AnesThesia for Robotic surgery' (AVATaR). The primary endpoint is the occurrence of one or more PPCs in the first five postoperative days. Secondary endpoints include the occurrence of each individual PPC, hospital length of stay and in-hospital mortality. Logistic regression models will be used to identify risk factors for PPCs in laparoscopic non-robotic versus laparoscopic robotic abdominal surgery. We will investigate whether differences in the occurrence of PPCs between the two groups are driven by differences in duration of anesthesia and/or the intensity of mechanical ventilation. This analysis will address a clinically relevant research question comparing laparoscopic and robotic assisted surgery. No additional ethical committee approval is required for this metanalysis. Data will be shared with the scientific community by abstracts and original articles submitted to peer-reviewed journals. The registration of this post-hoc analysis is pending; individual studies that were merged into the used database were registered at clinicaltrials.gov: LAS VEGAS with identifier NCT01601223, AVATaR with identifier NCT02989415. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/35432 | DOI: | 10.1016/j.redare.2024.07.001 | ORCID: | Journal: | Revista Espanola de Anestesiologia y Reanimacion | PubMed URL: | 38987020 | ISSN: | 2341-1929 | Type: | Journal Article | Subjects: | Cirugía laparoscópica Cirugía robótica Driving pressure Intensidad de la ventilación Laparoscopic surgery Mechanical power Mechanical power of ventilation Operating room Potencia mecánica Potencia mecánica de la ventilación Presión de impulso Quirófano Robotic surgery Ventilación Ventilation Ventilation intensity |
Appears in Collections: | Journal articles |
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