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Title: A novel therapy for intractable chronic cough.
Austin Authors: Bricknell, Matthew;Zhao, Chris Zi-Fan;Smallwood, Natasha;Goh, Nicole S L 
Affiliation: Respiratory and Sleep Medicine
Respiratory Research @ Alfred, Central Clinical School Monash University Melbourne Victoria Australia.
Institute for Breathing and Sleep
Issue Date: Mar-2024
Date: 2024
Publication information: Respirology Case Reports 2024-03; 12(3)
Abstract: Two cases of intractable chronic cough improved significantly with humidified high flow therapy (HHFT). A 59-year-old woman with Primary Sjogren's disease and interstitial lung disease, was trialled on a Fisher and Paykel myAIRVO™ system. She reported sustained benefits of uninterrupted sleep and increased socialization with tapering use of HHFT. A 67-year-old woman with idiopathic pulmonary fibrosis also benefited from the use of myAIRVO™. She had relentless cough with minimal movement, and nocturnal cough causing fragmented sleep. Her cough subsided considerably with continuous HHFT, but recurred without. Both patients reported significant reductions in the cough visual analogue scale. The mechanisms by which HHFT improve intractable cough may include reducing airway dryness, inhibition of neutrophil inflammation and mucus obstruction, and splinting of the airways. HHFT significantly improved cough and health-related quality of life in two patients with interstitial lung disease. Further research is warranted to explore the role of domiciliary HHFT.
DOI: 10.1002/rcr2.1323
ORCID: 0009-0006-2512-0705
Journal: Respirology Case Reports
Start page: e01323
PubMed URL: 38496302
Type: Journal Article
Subjects: chronic cough
humidified high flow therapy
intractable cough
Appears in Collections:Journal articles

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