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Title: Is there a temporal relationship between atrial fibrillation and stroke? A review.
Austin Authors: Dlima, Jessica;Kitisarn, Rooj;Lim, Han S ;Thijs, Vincent N 
Affiliation: The University of Melbourne-Parkville Campus, Melbourne, Victoria, Australia
Grampians Health Ballarat, Ballarat, Victoria, Australia.
The University of Melbourne-Parkville Campus, Melbourne, Victoria, Australia.;Department of Cardiology, Austin Health, Melbourne, VIC, Australia.
Melbourne Brain Centre-Austin Campus, Heidelberg, Victoria, Australia.
Issue Date: 2024
Date: 2024
Publication information: BMJ Neurology Open 2024; 6(1)
Abstract: Atrial fibrillation (AF) is an established risk factor for ischaemic stroke. The introduction of continuous cardiac rhythm monitoring devices has enabled detection of brief and asymptomatic episodes of AF. The search yielded 727 studies, 11 of which met the inclusion criteria. Four studies suggested a strong temporal association between episodes of AF and stroke, while seven indicated a weak relationship. The conflicting nature of the studies may be attributed to inconsistencies in ischaemic stroke verification (n=5/11), event rate and power (n=6/11) and lack of controlling for anticoagulation (n=10/11), mitigating the relationship between AF episodes and stroke. The temporal relationship between AF and stroke still remains unclear due to varying study methodology, lack of control for anticoagulation and inconsistent stroke subtyping. Our review identifies limitations to the current literature and makes recommendations for future studies assessing the temporal relationship between AF episodes and cardioembolic stroke.
DOI: 10.1136/bmjno-2023-000512
ORCID: 0000-0002-7281-3620
Journal: BMJ Neurology Open
Start page: e000512
PubMed URL: 38288314
ISSN: 2632-6140
Type: Journal Article
Appears in Collections:Journal articles

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