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https://ahro.austin.org.au/austinjspui/handle/1/35007| Title: | Mosquitoes provide a transmission route between possums and humans for Buruli ulcer in southeastern Australia. | Austin Authors: | Mee, Peter T;Buultjens, Andrew H;Oliver, Jane;Brown, Karen;Crowder, Jodie C;Porter, Jessica L;Hobbs, Emma C;Judd, Louise M;Taiaroa, George;Puttharak, Natsuda;Williamson, Deborah A;Blasdell, Kim R;Tay, Ee Laine;Feldman, Rebecca;Muzari, Mutizwa Odwell;Sanders, Chris;Larsen, Stuart;Crouch, Simon R;Johnson, Paul D R ;Wallace, John R;Price, David J;Hoffmann, Ary A;Gibney, Katherine B;Stinear, Timothy P;Lynch, Stacey E | Affiliation: | Centre for AgriBioscience, AgriBio, Agriculture Victoria, Bundoora, Victoria, Australia. Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. Infectious Diseases Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. Centre for AgriBioscience, AgriBio, Agriculture Victoria, Bundoora, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.;Victorian Infectious Diseases Reference Laboratory, Doherty Institute for Infection and Immunity, Melbourne Health, Melbourne, Victoria, Australia. Australian Centre for Disease Preparedness, CSIRO, Geelong, Victoria, Australia. Department of Health, Melbourne, Victoria, Australia. Medical Entomology, Tropical Public Health Services Cairns, Cairns and Hinterland Hospital and Health Services, Cairns, Queensland, Australia. Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. South East Public Health Unit, Monash Health, Clayton, Victoria, Australia. North East Public Health Unit, Austin Health, Heidelberg, Victoria, Australia. Department of Biology, Millersville University, Millersville, PA, USA. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia. Pest and Environmental Adaptation Research Group, School of BioSciences, Bio21 Institute, University of Melbourne, Parkville, Victoria, Australia. Department of Infectious Diseases, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.;WHO Collaborating Centre for Mycobacterium ulcerans, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Centre for AgriBioscience, AgriBio, Agriculture Victoria, Bundoora, Victoria, Australia.;Australian Centre for Disease Preparedness, CSIRO, Geelong, Victoria, Australia. |
Issue Date: | Feb-2024 | Date: | 2024 | Publication information: | Nature Microbiology 2024-02; 9(2) | Abstract: | Buruli ulcer, a chronic subcutaneous infection caused by Mycobacterium ulcerans, is increasing in prevalence in southeastern Australia. Possums are a local wildlife reservoir for M. ulcerans and, although mosquitoes have been implicated in transmission, it remains unclear how humans acquire infection. We conducted extensive field survey analyses of M. ulcerans prevalence among mosquitoes in the Mornington Peninsula region of southeastern Australia. PCR screening of trapped mosquitoes revealed a significant association between M. ulcerans and Aedes notoscriptus. Spatial scanning statistics revealed overlap between clusters of M. ulcerans-positive Ae. notoscriptus, M. ulcerans-positive possum excreta and Buruli ulcer cases, and metabarcoding analyses showed individual mosquitoes had fed on humans and possums. Bacterial genomic analysis confirmed shared single-nucleotide-polymorphism profiles for M. ulcerans detected in mosquitoes, possum excreta and humans. These findings indicate Ae. notoscriptus probably transmit M. ulcerans in southeastern Australia and highlight mosquito control as a Buruli ulcer prevention measure. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/35007 | DOI: | 10.1038/s41564-023-01553-1 | ORCID: | 0000-0002-3726-366X 0000-0002-5984-1328 0000-0001-7363-6665 0000-0003-2121-0376 0009-0003-5116-6393 0000-0003-4669-0273 0000-0001-9873-7163 0000-0002-8620-2628 0000-0003-0076-3123 0000-0001-9497-7645 0000-0001-5851-5339 0000-0003-0150-123X |
Journal: | Nature Microbiology | PubMed URL: | 38263454 | ISSN: | 2058-5276 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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