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Title
Which terms should be used to describe medications used in the treatment of seizure disorders? An ILAE position paper.
Publication Date
2024-01-27
Author(s)
Perucca, Emilio
French, Jacqueline A
Aljandeel, Ghaieb
Balestrini, Simona
Braga, Patricia
Burneo, Jorge G
Felli, Augustina Charway
Cross, J Helen
Galanopoulou, Aristea S
Jain, Satish
Jiang, Yuwu
Kälviäinen, Reetta
Lim, Shih Hui
Meador, Kimford J
Mogal, Zarine
Nabbout, Rima
Sofia, Francesca
Somerville, Ernest
Sperling, Michael R
Triki, Chahnez
Trinka, Eugen
Walker, Matthew C
Wiebe, Samuel
Wilmshurst, Jo M
Wirrell, Elaine
Yacubian, Elza Márcia
Kapur, Jaideep
Subject
antiepileptic drugs
antiseizure medications
recommendations
terminology
Type of document
Journal Article
OrcId
0000-0001-8703-223X
0000-0003-2242-8027
0000-0001-5684-0269
0000-0001-5639-1969
0000-0001-7928-375X
0000-0002-3644-2826
0000-0001-6618-2044
0000-0001-7345-4829
0000-0002-0472-2903
0000-0002-0085-6402
0000-0002-5179-9807
0000-0003-2935-5131
0000-0003-1420-0970
0000-0002-7471-882X
0000-0002-4685-2183
0000-0001-5877-4074
0000-0002-3172-2669
0000-0001-8789-1122
0000-0003-0708-6006
0000-0003-2918-3819
0000-0002-5950-2692
0000-0002-0812-0352
0000-0002-1061-9099
0000-0001-7328-1796
0000-0003-3015-8282
0000-0001-8367-0189
0000-0002-8608-1352
DOI
10.1111/epi.17877
Abstract
A variety of terms, such as "antiepileptic," "anticonvulsant," and "antiseizure" have been historically applied to medications for the treatment of seizure disorders. Terminology is important because using terms that do not accurately reflect the action of specific treatments may result in a misunderstanding of their effects and inappropriate use. The present International League Against Epilepsy (ILAE) position paper used a Delphi approach to develop recommendations on English-language terminology applicable to pharmacological agents currently approved for treating seizure disorders. There was consensus that these medications should be collectively named "antiseizure medications". This term accurately reflects their primarily symptomatic effect against seizures and reduces the possibility of health care practitioners, patients, or caregivers having undue expectations or an incorrect understanding of the real action of these medications. The term "antiseizure" to describe these agents does not exclude the possibility of beneficial effects on the course of the disease and comorbidities that result from the downstream effects of seizures, whenever these beneficial effects can be explained solely by the suppression of seizure activity. It is acknowledged that other treatments, mostly under development, can exert direct favorable actions on the underlying disease or its progression, by having "antiepileptogenic" or "disease-modifying" effects. A more-refined terminology to describe precisely these actions needs to be developed.
Link
Citation
Epilepsia 2024-01-27
Jornal Title
Epilepsia
ISSN
1528-1167

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