Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/34876
Title: Portal Hypertension in Malnutrition and Sarcopenia in Decompensated Cirrhosis-Pathogenesis, Implications and Therapeutic Opportunities.
Austin Authors: Terbah, Ryma ;Testro, Adam G ;Gow, Paul J ;Majumdar, Avik;Sinclair, Marie 
Affiliation: Victorian Liver Transplant Unit
Department of Medicine, The University of Melbourne, Parkville, VIC 3050, Australia.
Issue Date: 21-Dec-2023
Date: 2023
Publication information: Nutrients 2023-12-21; 16(1)
Abstract: Malnutrition and sarcopenia are highly prevalent in patients with decompensated cirrhosis and are associated with poorer clinical outcomes. Their pathophysiology is complex and multifactorial, with protein-calorie malnutrition, systemic inflammation, reduced glycogen stores and hormonal imbalances all well reported. The direct contribution of portal hypertension to these driving factors is however not widely documented in the literature. This review details the specific mechanisms by which portal hypertension directly contributes to the development of malnutrition and sarcopenia in cirrhosis. We summarise the existing literature describing treatment strategies that specifically aim to reduce portal pressures and their impact on nutritional and muscle outcomes, which is particularly relevant to those with end-stage disease awaiting liver transplantation.
URI: https://ahro.austin.org.au/austinjspui/handle/1/34876
DOI: 10.3390/nu16010035
ORCID: 0000-0003-0657-3048
Journal: Nutrients
PubMed URL: 38201864
ISSN: 2072-6643
Type: Journal Article
Subjects: cirrhosis
malnutrition
portal hypertension
sarcopenia
Sarcopenia/complications
Sarcopenia/therapy
Malnutrition/complications
Malnutrition/therapy
Protein-Energy Malnutrition/complications
Protein-Energy Malnutrition/therapy
Hypertension, Portal/complications
Hypertension, Portal/therapy
Liver Cirrhosis/complications
Liver Cirrhosis/therapy
Appears in Collections:Journal articles

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