Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/34739
Title: Improved Survival Outcomes with Surgical Resection Compared to Ablative Therapy in Early-Stage HCC: A Large, Real-World, Propensity-Matched, Multi-Centre, Australian Cohort Study.
Austin Authors: Abdelmalak, Jonathan;Strasser, Simone I;Ngu, Natalie;Dennis, Claude;Sinclair, Marie ;Majumdar, Avik;Collins, Kate;Bateman, Katherine;Dev, Anouk;Abasszade, Joshua H;Valaydon, Zina;Saitta, Daniel;Gazelakis, Kathryn;Byers, Susan;Holmes, Jacinta;Thompson, Alexander J;Pandiaraja, Dhivya;Bollipo, Steven;Sharma, Suresh;Joseph, Merlyn;Nicoll, Amanda;Batt, Nicholas;Sawhney, Rohit;Tang, Myo J;Lubel, John;Riordan, Stephen;Hannah, Nicholas;Haridy, James;Sood, Siddharth ;Lam, Eileen;Greenhill, Elysia;Majeed, Ammar;Kemp, William;Zalcberg, John;Roberts, Stuart K
Affiliation: Department of Gastroenterology, Alfred Health, Melbourne, VIC 3004, Australia.;Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Department of Gastroenterology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia.
Gastroenterology and Hepatology
Department of Gastroenterology, Monash Health, Clayton, VIC 3168, Australia.
Department of Gastroenterology, Western Health, Footscray, VIC 3011, Australia.
Department of Gastroenterology, St. Vincent's Hospital Melbourne, Fitzroy, VIC 3065, Australia.;Department of Medicine, St. Vincent's Hospital, University of Melbourne, Parkville, VIC 3052, Australia.
Department of Gastroenterology, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Department of Gastroenterology, Eastern Health, Box Hill, VIC 3128, Australia.;Department of Medicine, Eastern Health Clinical School, Box Hill, VIC 3128, Australia.
Department of Gastroenterology, Alfred Health, Melbourne, VIC 3004, Australia.
Department of Gastroenterology, Prince of Wales Hospital, Randwick, NSW 2031, Australia.
Department of Gastroenterology, Royal Melbourne Hospital, Parkville, VIC 3052, Australia.
Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.;School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Department of Gastroenterology, Alfred Health, Melbourne, VIC 3004, Australia.;Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.;Department of Medical Oncology, Alfred Health, Melbourne, VIC 3004, Australia.
Department of Gastroenterology, Alfred Health, Melbourne, VIC 3004, Australia.;Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Issue Date: 7-Dec-2023
Date: 2023
Publication information: Cancers 2023-12-07; 15(24)
Abstract: The optimal treatment approach in very-early and early-stage hepatocellular carcinoma (HCC) is not precisely defined, and there is ambiguity in the literature around the comparative efficacy of surgical resection versus ablation as curative therapies for limited disease. We performed this real-world propensity-matched, multi-centre cohort study to assess for differences in survival outcomes between those undergoing resection and those receiving ablation. Patients with Barcelona Clinic Liver Cancer (BCLC) 0/A HCC first diagnosed between 1 January 2016 and 31 December 2020 who received ablation or resection as initial treatment were included in the study. A total of 450 patients were included in the study from 10 major liver centres including two transplant centres. Following propensity score matching using key covariates, 156 patients were available for analysis with 78 in each group. Patients who underwent resection had significantly improved overall survival (log-rank test p = 0.023) and local recurrence-free survival (log rank test p = 0.027) compared to those who received ablation. Based on real-world data, our study supports the use of surgical resection in preference to ablation as first-line curative therapy in appropriately selected BCLC 0/A HCC patients.
URI: https://ahro.austin.org.au/austinjspui/handle/1/34739
DOI: 10.3390/cancers15245741
ORCID: 0000-0001-7550-8202
0000-0002-9383-3903
0000-0002-5341-0404
0000-0003-0657-3048
0000-0001-5469-4317
0000-0003-0354-1614
0000-0003-4785-3337
0000-0002-1855-2757
0000-0002-0845-3341
0000-0002-1146-4308
0000-0002-1244-3322
0000-0002-0787-7273
0000-0002-6624-0782
0000-0002-9015-7997
Journal: Cancers
PubMed URL: 38136287
Type: Journal Article
Subjects: ablation
early
hepatocellular carcinoma
resection
Appears in Collections:Major reviews / reports

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