Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/34427
Title: Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells.
Austin Authors: Park, Simone L;Christo, Susan N;Wells, Alexandria C;Gandolfo, Luke C;Zaid, Ali;Alexandre, Yannick O;Burn, Thomas N;Schröder, Jan;Collins, Nicholas;Han, Seong-Ji;Guillaume, Stéphane M;Evrard, Maximilien;Castellucci, Clara;Davies, Brooke;Osman, Maleika;Obers, Andreas;McDonald, Keely M;Wang, Huimeng;Mueller, Scott N;Kannourakis, George;Berzins, Stuart P;Mielke, Lisa A;Carbone, Francis R;Kallies, Axel;Speed, Terence P;Belkaid, Yasmine;Mackay, Laura K
Affiliation: Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.
Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC, Australia.;Fiona Elsey Cancer Research Institute, Ballarat, VIC, Australia.
Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.;Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC, Australia.;Fiona Elsey Cancer Research Institute, Ballarat, VIC, Australia.
Olivia Newton-John Cancer Research Institute
School of Mathematics and Statistics, The University of Melbourne, Melbourne, VIC, Australia.;Walter and Eliza Hall Institute for Medical Research, Parkville, VIC, Australia.
Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, USA.;NIAID Microbiome Program, NIAID, National Institutes of Health, Bethesda, MD, USA.
Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Issue Date: Dec-2023
Date: 2023
Publication information: Science (New York, N.Y.) 2023-12; 382(6674)
Abstract: Skin-resident CD8+ T cells include distinct interferon-γ-producing [tissue-resident memory T type 1 (TRM1)] and interleukin-17 (IL-17)-producing (TRM17) subsets that differentially contribute to immune responses. However, whether these populations use common mechanisms to establish tissue residence is unknown. In this work, we show that TRM1 and TRM17 cells navigate divergent trajectories to acquire tissue residency in the skin. TRM1 cells depend on a T-bet-Hobit-IL-15 axis, whereas TRM17 cells develop independently of these factors. Instead, c-Maf commands a tissue-resident program in TRM17 cells parallel to that induced by Hobit in TRM1 cells, with an ICOS-c-Maf-IL-7 axis pivotal to TRM17 cell commitment. Accordingly, by targeting this pathway, skin TRM17 cells can be ablated without compromising their TRM1 counterparts. Thus, skin-resident T cells rely on distinct molecular circuitries, which can be exploited to strategically modulate local immunity.
URI: https://ahro.austin.org.au/austinjspui/handle/1/34427
DOI: 10.1126/science.adi8885
ORCID: 0000-0003-1507-0864
0000-0002-0139-7105
0000-0001-9799-8353
0000-0002-3599-2455
0000-0002-2528-2783
0000-0002-6634-4098
0000-0003-1763-1418
0000-0001-5270-0605
0000-0003-2007-4608
0000-0002-2105-1160
0000-0002-7454-7514
0000-0001-6981-1192
0009-0005-8768-0153
0000-0003-2788-4478
0000-0003-0226-3982
0000-0002-3838-3989
0000-0001-6880-9795
0000-0003-0713-1882
0000-0002-9522-9320
0000-0001-7233-9466
0000-0002-6312-6968
0000-0002-5403-7998
0000-0001-9962-3571
0000-0002-8496-6632
Journal: Science (New York, N.Y.)
Start page: 1073
End page: 1079
PubMed URL: 38033053
ISSN: 1095-9203
Type: Journal Article
Appears in Collections:Journal articles

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