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Title: | Seminal papers in urology: maintenance Bacillus Calmette-Guerin (BCG) immunotherapy for recurrent Ta, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized southwest oncology group study (SWOG-8507). | Austin Authors: | Tempo, Jake;Bolton, Damien M ;O'Callaghan, Michael | Affiliation: | Austin Health College of Medicine and Public Health, Flinders University, Adelaide, Australia.;Flinders Medical Centre, Urology Unit, Adelaide, Australia.;Discipline of Medicine, The University of Adelaide, Adelaide, Australia. |
Issue Date: | 24-Nov-2023 | Date: | 2023 | Publication information: | BMC Urology 2023-11-24; 23(1) | Abstract: | The South West Oncology Group's 2000 randomised-control trial investigated the addition of maintenance intravesical bacillus Calmette-Guerin (BCG) to non-muscle invasive urothelial carcinoma (NMIUC) treatment. The results were published when the efficacy of BCG immunotherapy maintenance was unclear.Randomisation produced two arms, each containing 192 patients assessed to be at high risk of recurrence following induction BCG therapy for NMIUC. The treatment arm went on to receive three successive weekly intravesical and percutaneous BCG administrations at three months, six months and then six monthly for three years from the start of induction therapy.Recurrence free-survival (RFS), was higher in the maintenance arm with 41% (95%CI 35-49) RFS at five years in the control arm and 60% RFS (53-67 95% CI) in the maintenance arm (pā<ā0.0001). Only 16% of patients in the treatment arm received all of the scheduled maintenance courses of BCG.The study's seminal results correlate with contemporary systematic review and have guided international guidelines. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/34324 | DOI: | 10.1186/s12894-023-01352-0 | ORCID: | Journal: | BMC Urology | Start page: | 194 | PubMed URL: | 37996890 | ISSN: | 1471-2490 | Type: | Journal Article | Subjects: | BCG Bladder Cancer Randomised Controlled Trial Carcinoma, Transitional Cell/drug therapy Carcinoma, Transitional Cell/pathology Urinary Bladder Neoplasms/drug therapy BCG Vaccine/therapeutic use Urinary Bladder/pathology Carcinoma in Situ/pathology Carcinoma in Situ/therapy Neoplasm Recurrence, Local/pathology Adjuvants, Immunologic/therapeutic use |
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