Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/34292
Title: Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3.
Austin Authors: Thilakasiri, Pathum;O'Keefe, Ryan N;To, Sarah Q;Chisanga, David;Eissmann, Moritz F ;Carli, Annalisa LE;Duscio, Belinda;Baloyan, David;Dmello, Rhynelle S;Williams, David S ;Mariadason, John M ;Poh, Ashleigh R;Pal, Bhupinder;Kile, Benjamin T;Vissers, Joseph Ha;Harvey, Kieran F;Buchert, Michael ;Shi, Wei;Ernst, Matthias ;Chand, Ashwini L 
Affiliation: Olivia Newton-John Cancer Research Institute
School of Cancer Medicine, La Trobe University, Heidelberg, Australia.
Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.
Peter MacCallum Cancer Centre, Melbourne, Australia.
Department of Anatomy and Developmental Biology, and Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Issue Date: Feb-2024
Date: 2023
Publication information: Life Science Alliance 2024-02; 7(2)
Abstract: Deregulation of the Hippo pathway is a driver for cancer progression and treatment resistance. In the context of gastric cancer, YAP1 is a biomarker for poor patient prognosis. Although genomic tumor profiling provides information of Hippo pathway activation, the present study demonstrates that inhibition of Yap1 activity has anti-tumor effects in gastric tumors driven by oncogenic mutations and inflammatory cytokines. We show that Yap1 is a key regulator of cell metabolism, proliferation, and immune responses in normal and neoplastic gastric epithelium. We propose that the Hippo pathway is targetable across gastric cancer subtypes and its therapeutic benefits are likely to be mediated by both cancer cell-intrinsic and -extrinsic mechanisms.
URI: https://ahro.austin.org.au/austinjspui/handle/1/34292
DOI: 10.26508/lsa.202302411
ORCID: 0000-0002-8527-2165
0000-0002-0421-3957
0000-0002-2855-0616
0000-0001-9123-7684
0000-0002-8836-8947
0000-0003-0435-6824
0000-0003-2672-0148
0000-0002-6399-1177
0000-0002-1245-729X
Journal: Life Science Alliance
PubMed URL: 37957015
ISSN: 2575-1077
Type: Journal Article
Subjects: Stomach Neoplasms/genetics
Stomach Neoplasms/metabolism
Stomach Neoplasms/pathology
Adaptor Proteins, Signal Transducing/genetics
Adaptor Proteins, Signal Transducing/metabolism
Transcription Factors/genetics
Transcription Factors/metabolism
STAT3 Transcription Factor/metabolism
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